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Table 6 Association between miR-143 rs353298 A/G polymorphism and MCTD clinical parameters

From: Association study between immune-related miRNAs and mixed connective tissue disease

Pericarditis/pleuritis
miR-143 rs353298 A/G n (%) Model p OR 95% CI
  Genotype AA AG GG GG + AG vs AA 0.49 1.83 0.54 6.26
   Pericarditis/pleuritis 4 (11.11) 5 (12) 6 (35) AA + AG vs GG 0.04 4.18 1.24 14.07
   Without pericarditis/pleuritis 32 (88.89) 37 (88) 11 (65) GG + AA vs AG 0.52 0.58 0.18 1.85
  Allele A G   GG vs AA 0.04 4.36 1.04 18.39
   Pericarditis/pleuritis 13 (11) 17 (22)   AG vs AA 0.9129 1.08 0.27 4.37
   Without pericarditis/pleuritis 101 (89) 59 (78)   G vs A 0.05 2.24 1.02 4.93
Scleroderma
miR-143 rs353298 A/G n (%) Model p OR 95% CI
  Genotype AA AG GG GG + AG vs AA 0.87 0.84 0.35 2.01
   Scleroderma 13 (36.11) 17 (40) 2 (12) AA + AG vs GG 0.05 0.21 0.05 1
   Without scleroderma 23 (63.89) 25 (60) 15 (88) GG + AA vs AG 0.30 1.72 0.73 4.06
  Allele A G   GG vs AA 0.0814 0.24 0.05 1.2
   Scleroderma 43 (38) 21 (28)   AG vs AA 0.6929 1.2 0.48 3.01
   Without scleroderma 71 (62) 55 (72)   A vs G 0.1509 0.63 0.34 1.18
  1. n number of patients with clinical information; p value < 0.05 is considered significant, indicated in bold; p value obtained from χ2 or Fisher exact test