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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: The sequence of disease-modifying anti-rheumatic drugs: pathways to and predictors of tocilizumab monotherapy

Fig. 1

Sequences of biologic DMARDs among patients in Corrona who eventually used tocilizumab monotherapy. Each colored line represents a common sequence of treatments used by a subset of Corrona patients ending with TCZm use. For example, the left-most orange line illustrates the sequence bDMARD->TNF combo->Nonbiologics->TNF combo->TCZm. The number of markers on each line is equal to the number of treatments in the trajectory, looking back at most 4 steps before TCZm treatment. The thickness of a line correlates linearly with the number of patients following the corresponding sequence. The colored legend describes the sequences of DMARD treatments for these patients. Gray lines illustrate sequences with fewer than 4 occurrences. Abbreviations: TCZ, tocilizumab; DMARD, disease modifying anti-rheumatic drug; bDMARD, biologic DMARD; mono, DMARD monotherapy; combo, combination DMARD therapy

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