Fig. 2

Sequences of biologic DMARDs among patients in Corrona who eventually used TNF inhibitor monotherapy. Each colored line represents a common sequence of treatments used by a subset of Corrona patients ending with TNF inhibitor monotherapy. For example, the left-most yellow line illustrates the sequence TNF+NonBiologics->No recorded drug->NonBiologics->TNF+NonBiologics->TNF mono. The number of markers on each line is equal to the number of treatments (combinations) in the trajectory, looking back at most 4 steps before TCZm treatment. The thickness of a line correlates linearly with the number of patients following the corresponding sequence (with the exception of TNF+NonBiologics->TNF mono which is scaled down for the plot). The colored legend describes the sequences of DMARD treatments for these patients. Faint gray lines illustrate sequences with fewer than 5 occurrences. Abbreviations: Missing, no recorded drug use for 2 consecutive visits; TNF, tumor necrosis factor (inhibitor); DMARD, disease modifying anti-rheumatic drug; bDMARD, biologic DMARD; mono, monotherapy