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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Polysaccharide from Angelica sinensis attenuates SNP-induced apoptosis in osteoarthritis chondrocytes by inducing autophagy via the ERK1/2 pathway

Fig. 5

ASP activated the ERK1/2 signaling pathway in chondrocytes stimulated with SNP. Chondrocytes were pretreated with ASP for 4 h then stimulated with SNP (1 mg/ml) for 24 h. a, b. The level of Raf, Ras, p-MEK1/2, and p-ERK1/2 in chondrocytes after stimulation were measured by western blot. be. Quantitative analysis of Raf, Ras, p-MEK1/2, and p-ERK1/2 levels. The data are presented as the mean ± SD of three independent experiments (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001, #p < 0.0001, and statistical significance was determined by one-way ANOVA

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