Table 3 Univariable GEE, longitudinal associations of SLE clinical indicators with SLEQOL and SF36 survey scores
HRQoL survey outcomes | ||||||
|---|---|---|---|---|---|---|
SLEQOL-total score | SF36-PCS | SF36-MCS | ||||
Mean (95% CI) | RC (95% CI), p value | Mean (95% CI) | RC (95% CI), p value | Mean (95% CI) | RC (95% CI), p value | |
LLDAS status | ||||||
Not in LLDAS | 85.7 (84.4, 86.9) | Ref. | 46.2 (45.4, 47.0) | Ref. | 48.1 (47.2, 48.9) | Ref. |
In LLDAS | 88.7 (87.6, 89.9) | 3.0 (2.0, 4.0), p < 0.01 | 47.7 (46.9, 48.5) | 1.5 (0.9, 2.1), p < 0.01 | 49.7 (48.8, 50.6) | 1.6 (0.9, 2.4), p < 0.01 |
SLEDAI-2K | ||||||
SLEDAI-2K ≤ 4 | 88.0 (86.9, 89.2) | Ref. | 47.4 (46.7, 48.2) | Ref. | 49.2 (48.4, 50.0) | Ref. |
SLEDAI-2K > 4 | 84.8 (83.4, 86.3) | − 3.2 (− 4.4, − 2.0), p < 0.01 | 45.6 (44.6, 46.6) | − 1.8 (− 2.6, − 1.0), p < 0.01 | 47.8 (46.9, 48.8) | − 1.4 (− 2.2, − 0.5), p < 0.01 |
Flare | ||||||
Absent | 87.4 (86.2, 88.5) | Ref. | 47.2 (46.5, 47.9) | Ref. | 48.9 (48.1, 49.8) | Ref. |
Present | 85.7 (84.1, 87.3) | − 1.7 (− 2.8, − 0.5), p < 0.01 | 45.2 (44.2, 46.2) | − 2.0 (− 2.6, − 1.3), p < 0.01 | 48.3 (47.3, 49.4) | − 0.6 (− 1.4, 0.2), p = 0.15 |
Organ damage | ||||||
Absent | 88.4 (87.0, 89.8) | Ref. | 48.5 (47.7, 49.4) | Ref. | 48.8 (47.8, 49.8) | Ref. |
Present | 85.8 (84.2, 87.3) | − 2.6 (− 4.5, − .08), p < 0.01 | 45.3 (44.3, 46.3) | − 3.2 (− 4.4, − 2.1), p < 0.01 | 48.8 (47.7, 49.9) | 0.0 (− 1.4, 1.4), p = 0.9 |