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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis

Fig. 1

Analgesic effect of locally administered KML29 on MIA-induced secondary allodynia. On day 14 following intra-articular injection of MIA, the hindpaw withdrawal threshold was significantly reduced by local administration of KML29 (700 μg) over a 240-min time course (a) (P < 0.001; two-way ANOVA with Sidak post hoc test; *P < 0.05; n = 8–10). The analgesic effect of KML29 was blocked following administration of either the CB1R antagonist, AM281 (75 μg), or the CB2R antagonist, AM630 (75 μg) (b) (P < 0.0001; two-way ANOVA with Tukey post hoc test; **P < 0.01; ##P < 0.01; *P < 0.05; n = 6–10). Data are mean values ± SEM. ANOVA, analysis of variance; MIA, sodium monoiodoacetate; VEH, vehicle; *post hoc comparison between KML29 and VEH (a) and AM630 + KML29 to VEH + KML29 (b); #post hoc comparison between AM281 + KML29 and VEH + KML29 (b)

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