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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis

Fig. 2

Celecoxib dose-dependently improves pain and inflammation on day 1 of MIA-induced model of OA. MIA-induced secondary allodynia was present on day 1 of the model. Systemic administration of CXB dose-dependently improved the hindpaw withdrawal threshold over a 240-min time course (a) (P < 0.0001; two-way ANOVA with Tukey post hoc test; ##P < 0.01, #P < 0.05, *P < 0.05, $$P < 0.01, $P < 0.05, P < 0.001, P < 0.01, P < 0.05; n = 8). CXB dose-dependently decreased both rolling leukocytes (b) (P < 0.0001; one-way ANOVA with Tukey post hoc test; **P < 0.01; n = 8) and adherent leukocytes (c) (P < 0.0001; one-way ANOVA with Tukey post hoc test; ****P < 0.0001, **P < 0.01; n = 8) at 360 min post-drug administration. Data are mean values ± SEM. ANOVA, analysis of variance; BL, baseline; CXB, celecoxib; MIA, sodium monoiodoacetate; VEH, vehicle; #indicates post hoc comparison between 10 mg/kg and vehicle; *post hoc comparison between 3 and 10 mg/kg; post hoc comparison between 30 mg/kg and vehicle; $post hoc comparison between 3 and 30 mg/kg

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