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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis

Fig. 4

Early treatment with KML29 and celecoxib combination prevents MIA-induced secondary allodynia. Early treatment with combination of KML29 and CXB, given on days 1–3 post-MIA induction, significantly improve the hindpaw withdrawal threshold over the 14-day development of the model (P < 0.0001; two-way ANOVA with Tukey post hoc test; $P < 0.05, ****P < 0.0001, **P < 0.01, *P < 0.05, ###P < 0.001, ##P < 0.01, #P < 0.05, P < 0.001, P < 0.05; n = 8–10), compared to either treatment alone or vehicle. Data are mean values ± SEM. ANOVA, analysis of variance; BL, baseline; CXB, celecoxib; MIA, sodium monoiodoacetate; VEH, vehicle; *post hoc comparison between KML29 + CXB and vehicle; #post hoc comparison between KML29 and KML29 + CXB; $post hoc comparison between CXB and vehicle; post hoc comparison between CXB and KML29 + CXB

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