Fig. 3

Therapeutic effects of TAK-242 on physical symptoms in adjuvant-induced arthritis (AIA) rats. a In vivo experimental design and schedule. Wistar albino rats were immunized with complete Freud’s adjuvant (CFA) for AIA on day 0. On day 11, the vehicle group of rats was treated with vehicle alone (0.1% DMSO) and adjuvant-induced arthritic (AIA) rats were intraperitoneally (i.p.) treated with TAK-242 (3 mg or 5 mg of 0.1% DMSO/kg) daily until the 20th day. b Changes in body weight upon CFA immunization and TAK-242 treatment. TAK-242 treatment (5 mg/kg) significantly recovered the decreased body weight of AIA rats. c Macroscopic images of a representative rat displaying the gross features of paw joints on day 21. d Measurement of paw thickness during the experimental period. Values are expressed as mean ± standard error of the mean. ***P < 0.001 versus control group, ^##P < 0.01 versus arthritis model