Type of transition | Individual comorbid conditions | Combinations of comorbid conditions | ||||
---|---|---|---|---|---|---|
Obesity (vs no obesity)1 | DM (vs no DM)1 | CVD (vs no CVD)1 | Obesity and CVD (vs: no Obesity and no CVD)2 | Obesity and DM (vs: no Obesity and no DM)3 | CVD and DM (vs: no CVD and no DM)4 | |
n (vs n) for transitions | n (vs n) for transitions | |||||
aHR (95% CI) | aHR (95% CI) | |||||
Development of rHOA | ||||||
No rHOA/symptoms (A) to rHOA (B) | 82 (vs 116) | 39 (vs 159) | 69 (vs 129) | 16 (vs 75) | 12 (vs 103) | 6 (vs 103) |
0.88 (0.65, 1.18) | 1.06 (0.68, 1.63) | 1.34 (0.97, 1.85) | 1.27 (0.78, 2.06) | 0.89 (0.51, 1.55) | 0.79 (0.34, 1.85) | |
Symptoms only (C) to sxHOA (D) | 38 (vs 27) | 18 (vs 47) | 41 (vs 24) | 7 (vs 11) | 10 (vs 24) | 7 (vs 20) |
1.46 (0.91, 2.36) | 1.49 (0.86, 2.59) | 1.07 (0.65, 1.78) | 1.41 (0.63, 3.12) | 2.38 (1.23, 4.63) | 2.25 (1.08, 4.70) | |
Development of symptoms | ||||||
No rHOA/symptoms (A) to symptoms only (C) | 159 (vs 133) | 64 (vs 225) | 108 (vs 181) | 29 (vs 82) | 19 (vs 112) | 8 (vs 144) |
1.33 (1.01, 1.74) | 1.05 (0.71, 1.54) | 1.25 (0.92, 1.71) | 1.91 (1.21, 3.01) | 1.36 (0.84, 2.18) | 1.01 (0.50, 2.03) | |
rHOA (B) to sxHOA (D) | 87 (vs 85) | 39 (vs 133) | 71 (vs101) | 17 (vs 48) | 15 (vs 71) | 6 (vs 81) |
0.93 (0.63, 1.35) | 1.29 (0.78, 2.15) | 1.08 (0.71, 1.63) | 0.95 (0.52, 1.73) | 0.83 (0.43, 1.61) | 0.98 (0.38, 2.51) | |
Resolution of symptoms | ||||||
Symptoms only (C) to no rHOA/symptoms (A) | 164 (vs 137) | 67 (vs 234) | 107 (vs 194) | 34 (vs 85) | 26 (vs 115) | 14 (vs 151) |
0.88 (0.67, 1.14) | 0.74 (0.51, 1.08) | 0.61 (0.45, 0.82) | 0.56 (0.36, 0.86) | 0.65 (0.41, 1.04) | 0.46 (0.25, 0.84) | |
sxHOA (D) to rHOA (B) | 104 (vs 70) | 38 (vs 136) | 72 (vs 102) | 23 (vs 41) | 10 (vs 58) | 8 (vs 80) |
0.85 (0.58, 1.23) | 0.64 (0.38, 1.08) | 0.74 (0.50, 1.09) | 0.62 (0.35, 1.10) | 0.35 (0.17, 0.71) | 0.44 (0.21, 0.94) |