Fig. 4
From: Self-reactive T cells induce and perpetuate chronic relapsing arthritis
T cell ablation in rats with chronic PIA temporarily ameliorates the progression of disease. a Rats with early-stage chronic arthritis were treated with a mAb to αβTCR, or an isotype-matched control mAb, on day 67, 76, and 82 after pristane injection (arrow heads). Left: clinical scores. Right: relative weight change as compared to day 0. n = 13–14 rats/group. b Left: representative flow cytometric plots of peripheral blood mononuclear cells with gates depicting frequency of CD3+ cells (left) and CD4+ T cells (right) in T cell-depleted (bottom) and non-depleted (upper) rats on day 102 after pristane injection. Right: summary data of CD3+ and CD4+ T cell titers. The shading of the symbols represents the severity of arthritis on day 100 after pristane injection according to the enclosed legend. Data in a show mean values ± SD. Horizontal line in b depicts mean values. Statistical analyses as in Fig. 1