Fig. 5
From: Self-reactive T cells induce and perpetuate chronic relapsing arthritis
Neutralization of IL-17 efficiently blocks the progression of chronic disease in PIA. a Rats, which were part of the same cohort as those shown in Fig. 4, were treated with a mAb to IL-17, or an isotype-matched control mAb, on day 67, 76, and 82 after pristane injection (arrow heads). Left: clinical scores. Right: relative weight change as compared to day 0. n = 13–14 rats/group. b Representative images of front paws of rats injected with pristane (day 102 after injection) and treated with either IL-17 depleting or isotype control antibodies. c Left: representative flow cytometric plots of peripheral blood mononuclear cells with gates depicting frequency of granulocytes in IL-17-depleted (bottom) and non-depleted (upper) rats on day 102 after pristane injection. Right: summary data of granulocyte titers. d Representative flow cytometric plots and summary data for the percentage of IL-17+ and IFNγ+ CD4+ T cells on day 226 in the spleen. The colors of the symbols in c and d represent the severity of arthritis on day 100 after pristane injection according to the enclosed legends. Data in a show mean values ± SD. Horizontal line in c and d depicts mean values. Statistical analyses as in Fig. 1