Fig. 2

Evolution of imaging-assessed inflammation over time. BL, baseline, BME, bone marrow edema; 95%CI, 95% confidence interval; FV, follow-up visit; MRI, magnetic resonance imaging; US, ultrasonography. FV1 is the visit at the time of patient-reported hand flare. FV2 took place 7–10 days after FV1. FV3 took place 2–3 months after FV2. FV4 took place 7–10 days after FV3. The vertical dashed line marks the time of patient-reported flare