Table 3 Associations between clinical and patient-reported outcomes and MRI-detected inflammation: synovitis, tenosynovitis, and BME
Univariate model | Full multivariate model | Multivariate model after backward selection | ||||
|---|---|---|---|---|---|---|
Coefficient (95% CI) | p | Coefficient (95% CI) | p | Coefficient (95% CI) | p | |
MRI synovitis | ||||||
Flare | 1.60 (0.88; 2.31) | < 0.0001 | 0.82 (− 0.17; 1.80) | 0.10 | ||
SJC28 | 0.96 (0.61; 1.32) | < 0.0001 | 0.74 (0.29; 1.17) | 0.001 | 0.97 (0.62–1.32) | < 0.0001 |
CRP | 0.09 (0.03; 0.16) | 0.004 | 0.05 (− 0.02; 0.12) | 0.18 | ||
Pain (VAS) | 0.03 (0.01; 0.05) | 0.001 | 0.03 (− 0.00; 0.07) | 0.14 | ||
PGA (VAS) | 0.02 (0.00; 0.04) | 0.03 | − 0.04 (− 0.07; 0.00) | 0.08 | ||
HAQ | 0.70 (− 0.57; 1.98) | 0.28 | − 0.32 (− 1.80; 1.15) | 0.67 | ||
MRI tenosynovitis | ||||||
Flare | 1.79 (0.99; 2.59) | < 0.0001 | 1.15 (0.05; 2.25) | 0.04 | 1.15 (0.12–2.18) | 0.029 |
SJC28 | 0.70 (0.27; 1.12) | 0.012 | 0.02 (− 0.50; 0.50) | 0.95 | ||
CRP | 0.16 (0.08; 0.24) | < 0.0001 | 0.15 (0.06; 0.23) | < 0.0001 | 0.15 (0.07–0.22) | < 0.0001 |
Pain (VAS) | 0.04 (0.02; 0.06) | 0.0001 | 0.06 (0.02; 0.10) | 0.006 | 0.06 (0.02–0.10) | 0.004 |
PGA (VAS) | 0.03 (0.01; 0.05) | 0.013 | − 0.06 (− 0.10; − 0.01) | 0.009 | − 0.06 (− 0.10–0.02) | 0.006 |
HAQ | 1.00 (− 0.46; 2.52) | 0.18 | 0.15 (−1.60; 1.90) | 0.87 | ||
MRI BME* | ||||||
Flare | 0.05 (− 0.05; 0.15) | 0.29 | − 0.70 (− 0.21; 0.07) | 0.32 | ||
SJC28 | 0.06 (0.01; 0.11) | 0.017 | 0.07 (0.01; 0.14) | 0.02 | 0.06 (0.01–0.11) | 0.017 |
CRP | 0.01 (0.00; 0.01) | 0.21 | − 0.00 (− 0.01; 0.00) | 0.63 | ||
Pain (VAS) | 0.00 (0.00; 0.00) | 0.16 | 0.00 (− 0.00; 0.01) | 0.53 | ||
PGA (VAS) | 0.00 (0.00; 0.00) | 0.17 | 0.00 (− 0.01; 0.01) | 0.94 | ||
HAQ | 0.09 (− 0.09; 0.27) | 0.33 | − 0.03 (− 0.28; 0.91) | 0.75 | ||