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Table 3 Associations between clinical and patient-reported outcomes and MRI-detected inflammation: synovitis, tenosynovitis, and BME

From: Serial magnetic resonance imaging and ultrasound examinations demonstrate differential inflammatory lesion patterns in soft tissue and bone upon patient-reported flares in rheumatoid arthritis

 Univariate modelFull multivariate modelMultivariate model after backward selection
Coefficient (95% CI)pCoefficient (95% CI)pCoefficient (95% CI)p
MRI synovitis
 Flare1.60 (0.88; 2.31)< 0.00010.82 (− 0.17; 1.80)0.10  
 SJC280.96 (0.61; 1.32)< 0.00010.74 (0.29; 1.17)0.0010.97 (0.62–1.32)< 0.0001
 CRP0.09 (0.03; 0.16)0.0040.05 (− 0.02; 0.12)0.18  
 Pain (VAS)0.03 (0.01; 0.05)0.0010.03 (− 0.00; 0.07)0.14  
 PGA (VAS)0.02 (0.00; 0.04)0.03− 0.04 (− 0.07; 0.00)0.08  
 HAQ0.70 (− 0.57; 1.98)0.28− 0.32 (− 1.80; 1.15)0.67  
MRI tenosynovitis
 Flare1.79 (0.99; 2.59)< 0.00011.15 (0.05; 2.25)0.041.15 (0.12–2.18)0.029
 SJC280.70 (0.27; 1.12)0.0120.02 (− 0.50; 0.50)0.95  
 CRP0.16 (0.08; 0.24)< 0.00010.15 (0.06; 0.23)< 0.00010.15 (0.07–0.22)< 0.0001
 Pain (VAS)0.04 (0.02; 0.06)0.00010.06 (0.02; 0.10)0.0060.06 (0.02–0.10)0.004
 PGA (VAS)0.03 (0.01; 0.05)0.013− 0.06 (− 0.10; − 0.01)0.009− 0.06 (− 0.10–0.02)0.006
 HAQ1.00 (− 0.46; 2.52)0.180.15 (−1.60; 1.90)0.87  
MRI BME*
 Flare0.05 (− 0.05; 0.15)0.29− 0.70 (− 0.21; 0.07)0.32  
 SJC280.06 (0.01; 0.11)0.0170.07 (0.01; 0.14)0.020.06 (0.01–0.11)0.017
 CRP0.01 (0.00; 0.01)0.21− 0.00 (− 0.01; 0.00)0.63  
 Pain (VAS)0.00 (0.00; 0.00)0.160.00 (− 0.00; 0.01)0.53  
 PGA (VAS)0.00 (0.00; 0.00)0.170.00 (− 0.01; 0.01)0.94  
 HAQ0.09 (− 0.09; 0.27)0.33− 0.03 (− 0.28; 0.91)0.75  
  1. BME bone marrow edema, CRP C-reactive protein, HAQ health assessment questionnaire, MRI magnetic resonance imaging, PGA patient’s global assessment, SJC28 swollen joint count assessed in 28 joints, VAS visual analog scale. All multivariate mixed effect linear regression models are adjusted for age, sex, and disease duration at baseline. *log transformed
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