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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Aryl hydrocarbon receptor signals attenuate lung fibrosis in the bleomycin-induced mouse model for pulmonary fibrosis through increase of regulatory T cells

Fig. 6

Chronologic changes in the number of Tregs, CD4+IFNγ+ and γδ+IL-17A+ T cells after BLM administration. BLM at 0.06 units/animal was intratracheally administered with (denoted as FICZ) or without FICZ (vehicle). PBS was intratracheally administered as a control of BLM. Mice were sacrificed 1 and 3 weeks after administration for flow cytometric analysis. Total number of CD3+CD4+T cells (a), CD3+γδ+ T cells (b), CD4+Foxp3+ Tregs (c), CD4+IFNγ+ T cells (d), and γδ+IL-17A+ T cells (e) were compared among the three groups. n = 5 in each group. *p < 0.05 BLM with FICZ or BLM with vehicle compared to PBS with FICZ using Mann-Whitney test. p < 0.05 BLM with FICZ compared to BLM with vehicle, and BLM with vehicle compared to PBS with FICZ using Mann-Whitney test. p < 0.05 BLM with vehicle compared to BLM with FICZ or PBS with vehicle using Mann-Whitney test. §p < 0.05 BLM with vehicle compared to BLM with FICZ, and BLM with FICZ compared to PBS with FICZ using Mann-Whitney test

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