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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Reduction of circulating innate lymphoid cell progenitors results in impaired cytokine production by innate lymphoid cells in patients with lupus nephritis

Fig. 1

Patients with LN show reduced percentages of CD117+ ILCs in the circulation and in renal tissue. a Gating strategy for blood ILCs. b Representative flow cytometry plots of ILC subsets within the PBMC. c Percentage of total ILCs (CD45+ Lin CD127+), CD117+ ILCs, CRTH2+ ILCs, and CD117/CRTH2 ILCs within the PBMC from HC (n = 8), LN (n = 12), AAV (n = 5), IgAN (n = 8), and MCD/FSGS (n = 5). d Representative flow cytometry plots of ILC subsets in urine. e Percentage of CD117+ ILCs and CRTH2+ ILCs in urine from patients with LN (n = 15), AAV (n = 6), IgAN (n = 9), and MCD/FSGS (n = 5). *P < 0.05; **P < 0.01; ***P < 0.001 (Student’s t test). ##P < 0.01 (Mann-Whitney test). ILC, innate lymphoid cell; PBMC, peripheral blood mononuclear cell; HC, healthy control; LN, lupus nephritis; AAV, ANCA-associated vasculitis; IgAN, IgA nephropathy; MCD, minimal change disease; FSGS, focal segmental glomerulosclerosis

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