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Table 2 Pneumococcal serotype-specific IgG GMC (95% confidence interval [CI]) in μg/mL before vaccination, post-PCV and post-PPV23 in treatment groups and controls

From: Prime-boost vaccination strategy enhances immunogenicity compared to single pneumococcal conjugate vaccination in patients receiving conventional DMARDs, to some extent in abatacept but not in rituximab-treated patients

  Rituximab (n = 30) Abatacept (n = 23) cDMARD (n = 27) Controls (n = 28)
Serotype Pre-PCV Post-PCV Post-PPV23 Pre-PCV13 Post-PCV13 Post-PPV23 Pre-PCV13 Post-PCV13 Post-PPV23 Pre-PCV13 Post-PCV13 Post-PPV23
1 0.11 (0.06–0.21) 0.37 (0.19–0.73) 0.40 (0.22–0.73) 0.10 (0.05–0.18) 0.27 (0.12–0.62) 0.84 (0.40–1.77) 0.12 (0.08–0.16) 1.09 (0.58–2.03) 3.21 (1.80–5.75)
3 0.10 (0.05–0.19) 0.35 (0.12–1.01) 0.38 (0.15–0.98) 0.06 (0.03–0.11) 0.14 (0.07–0.25) 0.21 (0.10–0.45) 0.08 (0.04–0.16) 0.68 (0.33–1.40) 1.90 (0.83–4.36)
4 0.13 (0.07–0.23) 0.17 (0.10–0.29) 0.12 (0.07–0.21) 0.13 (0.07–0.24) 0.28 (0.14–0.58) 0.29 (0.14–0.60) 0.11 (0.07–0.17) 0.36 (0.19–0.69) 0.77 (0.29–2.02) 0.18 (0.12–0.28) 2.15 (1.09–4.26) 4.07 (1.93–8.56)
5 0.17 (0.07–0.43) 0.48 (0.20–1.14) 0.53 (0.23–1.24) 0.11 (0.07–0.17) 0.54 (0.23–1-27) 0.89 (0.39–2.08) 0.09 (0.06–0.13) 0.61 (0.36–1.03) 1.52 (0.77–3.00)
6B 0.16 (0.09–0.29) 0.22 (0.11–0.42) 0.17 (0.08–0.34) 0.20 (0.10–0.39) 0.77 (0.33–1.79) 0.76 (0.33–1.77) 0.17 (0.08–0.38) 0.62 (0.27–1.43) 0.67 (0.28–1.65) 0.16 (0.07–0.33) 1.32 (0.56–3.14) 2.41 (1.02–5.69)
7F 0.31 (0.20–0.46) 1.80 (0.90–3.60) 1.89 (0.95–3.74) 0.51 (0.29–0.91) 2.57 (1.31–5,05) 2.42 (1.25–4.68) 0.23 (0.12–0.46) 3.48 (2.02–6.02) 4.04 (2.03–8.05)
9V 0.15 (0.08–0.25) 0.17 (0.10–0.30) 0.14 (0.08–0.24) 0.22 (0.11–0.45) 0.93 (0.45–1.91) 0.92 (0.44–1.96) 0.12 (0.07–0.23) 0.58 (0.26–1.26) 0.58 (0.32–1.07) 0.15 (0.09–0.25) 1.60 (0.87–2.94) 1.94 (1.09–3.47)
14 3.15 (1.70–5.82) 3.93 (2.22–6.96) 3.24 (1.84–5.79) 1.60 (0.70–3.71) 5.89 (3.10–11.18) 6.44 (3.61–11.49) 0.54 (0.26–1.11) 2.89 (1.31–6.33) 3.28 (1.66–6.46) 1.10 (0.50–2.43) 6.77 (3.50–13.12) 13.07 (9.36–18.26)
18C 0.69 (0.43–1.10) 0.83 (0.53–1.31) 0.60 (0.36–1.00) 0.76 (0.35–1.63) 3.90 (1.97–7.72) 4.21 (2.32–7.63) 0.41 (0.24–0.71) 2.83 (1.76–4.56) 2.37 (1.42–3.95) 1.03 (0.59–1.81) 5.74 (3.91–8.41) 6.33 (4,07–9.82)
19A 0.31 (0.12–0.80) 1.01 (0.37–2.76) 1.05 (0.37–3.02) 0.20 (0.09–0.43) 0.86 (0.33–2.29) 0.71 (0.27–1.88) 0.20 (0.08–0.47) 1.40 (0.60–3.29) 2.19 (0.94–5.07)
19F 0.84 (0.51–1.39) 0.96 (0.58–1.60) 0.64 (0.38–1.09) 0.76 (0.39–1.46) 1.25 (0.68–2.33) 1.53 (0.74–3.14) 0.85 (0.46–1.60) 1.89 (0.83–4.32) 4.38 (1.76–10.93 0.78 (0.48–1.25) 3.09 (1.59–6.03) 12.52 (5.35–29.30)
23F 0.32 (0.20–0.53) 0.41 (0.26–0.66) 0.34 (0.21–0.55) 0.70 (0.40–1.23) 3.10 (1.50–6.36) 2.83 (1.35–5.93) 0.34 (0.19–0.62) 1.17 (0.50–2.74) 1.46 (0.73–2.94) 0.41 (0.23–0.71) 6.12 (3.23–11.61) 6.30 (3.25–12.21)
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