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Table 1 Characteristics of the three groups

From: Unstimulated whole saliva flow for diagnosis of primary Sjögren’s syndrome: time to revisit the threshold?

 MenWomen < 50Women ≥ 50p value
Number of patients3842105 
Age (years)57 [46–68]37 [30–46]64 [55–68]< 0.0001
pSS16 (42.1%)16 (38.1%)61 (58.1%)0.048
Treatments inducing oral and/or ocular dryness5 (13.2%)10 (23.8%)28 (26.7%)0.24
Subjective DES28 (73.7%)40 (95.2%)95 (90.5%)< 0.01
Schirmera (mm/5 min)1 [0–3]5 [1–17.3]1 [0–4]< 0.001
Schirmer ≤ 5 mm/5 min33 (86.8%)25 (59.5%)90 (85.7%)< 0.001
OSS realization10 (26.3%)10 (23.8%)29 (27.6%)0.69
OSS ≥ 5 (if examination was realized)b1/10 (10.0%)2/10 (20.0%)8/29 (27.6%)0.51
Subjective DMS30 (78.9%)37 (88.1%)99 (94.3%)0.026
UWS flow (mL/min)0.27 [0.08–0.42]0.21 [0.09–0.46]0.20 [0.07–0.33]0.25
UWS flow rate ≤ 0.1 mL/min11 (28.9%)13 (31.0%)40 (38.1%)0.51
Anti-SSA antibodies4 (10.5%)9 (21.4%)22 (21.0%)0.35
Anti-SSB antibodies5 (13.2%)6 (14.3%)16 (15.2%)0.95
ANA > 1/20012 (31.6%)12 (28.6%)32 (30.5%)0.96
Focus score ≥ 1 on MSGB15 (39.5%)17 (40.5%)61 (58.1%)0.051
  1. ANA anti-nuclear antibodies, MSGB minor salivary gland biopsy, UWS unstimulated whole saliva, OSS ocular staining score, pSS primary Sjögren’s syndrome, DMS dry mouth syndrome, DES dry eye syndrome
  2. aLowest value of both eyes
  3. bThe percentage given corresponds to the proportion of patients with an OSS ≥ 5 among those who underwent this examination
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