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Table 3 Diagnostic performances of unstimulated whole saliva flow rate with the adapted score from ACR/EULAR 2016 criteria for pSS according to the threshold

From: Unstimulated whole saliva flow for diagnosis of primary Sjögren’s syndrome: time to revisit the threshold?

 

Whole population

Men

Women < 50

Women > 50

UWS (mL/min)

≤ 0.1

≤ 0.2

≤ 0.1

≤ 0.2

≤ 0.1

≤ 0.2

≤ 0.1

≤ 0.2

Diagnostic performances of UWS flow rate with the adapted ACR/EULAR 2016 score

 Se

43.0 [32.8–53.7]

62.8 [52.2–72.5]

56.3 [29.9–80.2]

75.0 [47.6–92.7]

50.0 [24.7–75.3]

82.4 [56.6–96.2]

37.7 [25.6–51.0]

54.1 [40.8–66.9]

 Sp

73.9 [63.7–82.5]

65.2 [54.6–74.9]

90.9 [70.8–98.9]

81.8 [59.7–94.8]

80.8 [60.6–93.4]

76.0 [54.9–90.6]

61.4 [45.5–75.6]

52.3 [36.7–67.5]

 YI

0.17

0.28

0.47

0.57

0.31

0.58

− 0.01

0.06

 PPV

62.5 [49.5–74.3]

64.8 [54.1–74.6]

81.8 [48.2–97.7]

75.0 [47.6–92.7]

61.5 [31.6–86.1]

70.0 [45.7–88.1]

57.5 [40.9–73.0]

61.1 [46.9–74.1]

 NPV

56.2 [46.9–65.2]

63.2 [52.6–72.8]

74.1 [53.7–88.9]

81.8 [59.7–94.8]

72.4 [52.8–87.3]

86.4 [65.1–97.1]

41.5 [29.4–54.4]

45.1 [31.1–59.7]

  1. The adapted ACR/EULAR 2016 score was adapted from the ACR/EULAR 2016 classification criteria by modifying the level of the UWS flow rate cutoff to give 1 point for this item: a patient presenting a UWS flow lower than or equal to our tested threshold obtained 1 point on the adapted score
  2. UWS unstimulated whole saliva, Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, YI Youden’s index