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Table 3 Diagnostic performances of unstimulated whole saliva flow rate with the adapted score from ACR/EULAR 2016 criteria for pSS according to the threshold

From: Unstimulated whole saliva flow for diagnosis of primary Sjögren’s syndrome: time to revisit the threshold?

 Whole populationMenWomen < 50Women > 50
UWS (mL/min)≤ 0.1≤ 0.2≤ 0.1≤ 0.2≤ 0.1≤ 0.2≤ 0.1≤ 0.2
Diagnostic performances of UWS flow rate with the adapted ACR/EULAR 2016 score
 Se43.0 [32.8–53.7]62.8 [52.2–72.5]56.3 [29.9–80.2]75.0 [47.6–92.7]50.0 [24.7–75.3]82.4 [56.6–96.2]37.7 [25.6–51.0]54.1 [40.8–66.9]
 Sp73.9 [63.7–82.5]65.2 [54.6–74.9]90.9 [70.8–98.9]81.8 [59.7–94.8]80.8 [60.6–93.4]76.0 [54.9–90.6]61.4 [45.5–75.6]52.3 [36.7–67.5]
 YI0.170.280.470.570.310.58− 0.010.06
 PPV62.5 [49.5–74.3]64.8 [54.1–74.6]81.8 [48.2–97.7]75.0 [47.6–92.7]61.5 [31.6–86.1]70.0 [45.7–88.1]57.5 [40.9–73.0]61.1 [46.9–74.1]
 NPV56.2 [46.9–65.2]63.2 [52.6–72.8]74.1 [53.7–88.9]81.8 [59.7–94.8]72.4 [52.8–87.3]86.4 [65.1–97.1]41.5 [29.4–54.4]45.1 [31.1–59.7]
  1. The adapted ACR/EULAR 2016 score was adapted from the ACR/EULAR 2016 classification criteria by modifying the level of the UWS flow rate cutoff to give 1 point for this item: a patient presenting a UWS flow lower than or equal to our tested threshold obtained 1 point on the adapted score
  2. UWS unstimulated whole saliva, Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, YI Youden’s index
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