Table 1 Association analysis of rs2231142, rs10011796 (ABCG2) and rs11942223 (SLC2A9) in European and NZ Polynesian sample sets
| SNP | Raw N | Genotype, N (%)† | Effect allele, N (%) |
Gout vs. HU*^ OR (95% CI), P |
Gout vs. All Controls* OR (95% CI), P |
HU vs. NU* OR, 95% CI, P | ||
|---|---|---|---|---|---|---|---|---|
| rs2231142 | GG | GT | TT | T | ||||
| European gout | 1637 | 1006 (61.5) | 551 (33.7) | 80 (7.5) | 711 (21.7) |
1.81 (1.60–2.06), 3.0E−20 1.85 (1.63–2.11), 3.8E−21 | 2.42 (2.18–2.68), 1.9E−64 | – |
| European HU | 2378 | 1762 (74.1) | 577 (24.3) | 39 (1.6) | 655 (13.8) | 1.56 (1.41–1.72), 1.7E−18 | ||
| European NU | 11,604 | 9428 (81.2) | 2053 (17.7) | 123 (1.1) | 2299 (9.1) | |||
| WP# gout | 369 | 96 (26.0) | 189 (51.2) | 84 (22.8) | 357 (48.4) |
1.96 (1.30–3.00), 1.6E−03 1.77 (1.14–2.80), 0.012‡ | 2.36 (1.73–3.26), 1.1E−07 | – |
| WP HU | 88 | 48 (54.6) | 29 (33.0) | 11 (12.5) | 51 (29.0) | 1.52 (0.94–2.50), 0.091‡ | ||
| WP NU | 146 | 84 (57.5) | 52 (35.6) | 10 (6.9) | 72 (24.7) | – | ||
| EP# gout | 543 | 436 (80.3) | 106 (19.5) | 1 (0.2) | 108 (9.9) |
1.99 (1.05–4.05), 0.044 2.02 (1.05–4.16) 0.043‡ | 2.54 (1.66–3.97), 3.4E−05 | – |
| EP HU | 114 | 101 (88.6) | 13 (11.4) | 0 (0.0) | 13 (5.7) | 1.41 (0.65–2.93), 0.37‡ | ||
| EP NU | 348 | 315 (90.5) | 32 (9.2) | 1 (0.3) | 34 (4.9) | |||
| rs10011796 | CC | CT | TT | T | ||||
| European gout | 1580 | 339 (21.5) | 764 (48.4) | 477 (30.2) | 1718 (54.4) |
1.39 (1.26–1.53), 2.0E−11 1.39 (1.26–1.53), 3.5E−11 | 1.55 (1.44–1.69), 1.3E−27 | – |
| European HU | 2422 | 666 (27.5) | 1208 (49.9) | 548 (22.6) | 2304 (47.6) | 1.18 (1.10–1.26), 7.8E−07 | ||
| European NU | 11,927 | 3688 (30.9) | 5986 (50.2) | 2253 (18.9) | 10,492 (44.0) | – | ||
| WP gout | 369 | 38 (10.3) | 163 (44.2) | 168 (45.5) | 499 (67.6) |
1.28 (0.86–1.91), 0.22 1.27 (0.83–1.94), 0.27 | 1.32 (0.99–1.77), 0.062 | – |
| WP HU | 88 | 10 (11.4) | 43 (48.9) | 35 (39.8) | 113 (64.2) | 1.02 (0.66–1.60), 0.92 | ||
| WP NU | 146 | 21 (14.4) | 67 (45.9) | 58 (39.3) | 183 (62.7) | |||
| EP gout | 543 | 93 (17.2) | 259 (47.9) | 189 (34.9) | 637 (58.9) |
0.94 (0.68–1.29), 0.69 0.92 (0.66–1.27), 0.60 | 1.03 (0.83–1.27), 0.80 | – |
| EP HU | 114 | 18 (15.8) | 51 (44.7) | 45 (39.5) | 141 (61.8) | 1.13 (0.81–1.57), 0.48 | ||
| EP NU | 348 | 67 (19.3) | 173 (49.7) | 108 (31.0) | 389 (55.9) | |||
| rs11942223 | TT | TC | CC | C | ||||
| European gout | 1576 | 1168 (74.1) | 382 (24.2) | 26 (1.6) | 434 (13.8) |
0.72 (0.63–0.83), 2.9E−06 0.73 (0.63–0.83), 4.7E−06 | 0.55 (0.49–0.62), 1.4E−25 | – |
| European HU | 2422 | 1658 (68.5) | 701 (28.9) | 63 (2.6) | 827 (17.1) | 0.66 (0.61–0.73), 2.2E−21 | ||
| European NU | 11,927 | 7101 (59.5) | 4220 (35.4) | 606 (5.1) | 5432 (22.8) | |||
| WP gout | 369 | 351 (95.1) | 18 (4.9) | 0 (0.0) | 18 (2.4) |
0.53 (0.17–2.05), 0.31 0.51 (0.15–2.08), 0.31 | 0.61 (0.26–1.46), 0.26 | – |
| WP HU | 88 | 84 (95.5) | 4 (4.6) | 0 (0.0) | 4 (2.3) | 0.83 (0.20–2.94), 0.78 | ||
| WP NU | 146 | 135 (92.5) | 11 (7.5) | 0 (0.0) | 11 (3.8) | |||
| EP gout | 543 | 501 (92.3) | 39 (7.2) | 3 (0.6) | 45 (4.1) |
1.04 (0.47–2.61), 0.92 1.24 (0.54–3.23), 0.64 | 1.06 (0.62–1.84), 0.84 | – |
| EP HU | 114 | 105 (92.1) | 9 (7.9) | 0 (0.0) | 9 (3.9) | 1.26 (0.51–12.94), 0.60 | ||
| EP NU | 348 | 311 (89.4) | 37 (10.6) | 0 (0.0) | 37 (5.3) | |||