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Table 2 Association analysis of rs2231142, rs10011796 (ABCG2) and rs11942223 (SLC2A9) with serum urate at recruitment (mmol/L) in European and NZ Polynesian controls

From: Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout

SNP/allele

Combined sex*

Male only*

N

β mmol/L (SE)

P

N

β mmol/L (SE)

P

rs2231142/T

 European control

13,982

0.017 (1.5E−03)

8.9E−30

6514

0.020 (2.2E−03)

5.7E−20

 WP control

234

0.019 (9.2E−03)

0.035

134

0.027 (0.011)

0.017

 EP control

462

0.015 (0.012)

0.19

190

0.009 (0.023)

0.68

Polynesian meta-analysis

696

0.018 (7.2E−03)

0.014

324

0.024 (0.010)

0.019

rs10011796/T

 European control

14,349

0.006 (9.2E−04)

1.7E−10

6682

0.006 (4.7E−03)

1.5E−06

 WP control

234

0.006 (8.5E−03)

0.51

134

0.006 (0.011)

0.62

 EP control

462

0.005 (5.0E−03)

0.33

190

0.000 (8.1E−03)

0.99

Polynesian meta-analysis

696

0.005 (4.3E−03)

0.94

324

0.002 (6.6E−03)

0.77

rs11942223/C

 European control

14,349

− 0.024 (1.1E−03)

8.4E−106

6681

− 0.017 (1.6E−03)

8.1E−27

 WP control

234

− 0.021 (0.023)

0.38

134

− 0.038 (0.038)

0.32

 EP control

462

− 0.008 (0.012)

0.53

190

0.052 (0.022)

0.022

Polynesian meta-analysis^

696

− 0.011 (0.011)

0.63

324

0.012 (0.044)

0.78

  1. *European sample set adjusted by age and sex (combined sex only). Polynesian sample sets additionally adjusted by PCs 1–10
  2. ^As the test for heterogeneity between Western Polynesian (WP) and Eastern Polynesian (EP) was significant (p = 0.043), a random effects model was used
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Arthritis Research & Therapy

ISSN: 1478-6362

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