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Table 2 Association analysis of rs2231142, rs10011796 (ABCG2) and rs11942223 (SLC2A9) with serum urate at recruitment (mmol/L) in European and NZ Polynesian controls

From: Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout

SNP/allele Combined sex* Male only*
N β mmol/L (SE) P N β mmol/L (SE) P
rs2231142/T
 European control 13,982 0.017 (1.5E03) 8.9E−30 6514 0.020 (2.2E03) 5.7E−20
 WP control 234 0.019 (9.2E03) 0.035 134 0.027 (0.011) 0.017
 EP control 462 0.015 (0.012) 0.19 190 0.009 (0.023) 0.68
Polynesian meta-analysis 696 0.018 (7.2E−03) 0.014 324 0.024 (0.010) 0.019
rs10011796/T
 European control 14,349 0.006 (9.2E04) 1.7E−10 6682 0.006 (4.7E03) 1.5E−06
 WP control 234 0.006 (8.5E03) 0.51 134 0.006 (0.011) 0.62
 EP control 462 0.005 (5.0E03) 0.33 190 0.000 (8.1E03) 0.99
Polynesian meta-analysis 696 0.005 (4.3E−03) 0.94 324 0.002 (6.6E−03) 0.77
rs11942223/C
 European control 14,349  0.024 (1.1E03) 8.4E−106 6681 0.017 (1.6E03) 8.1E−27
 WP control 234  0.021 (0.023) 0.38 134 0.038 (0.038) 0.32
 EP control 462  0.008 (0.012) 0.53 190 0.052 (0.022) 0.022
Polynesian meta-analysis^ 696 − 0.011 (0.011) 0.63 324 0.012 (0.044) 0.78
  1. *European sample set adjusted by age and sex (combined sex only). Polynesian sample sets additionally adjusted by PCs 1–10
  2. ^As the test for heterogeneity between Western Polynesian (WP) and Eastern Polynesian (EP) was significant (p = 0.043), a random effects model was used