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Table 5 Risk of gout in rs2231142-rs10011796 genotype combinations classified by absence/presence of gout risk alleles

From: Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout

GenotypeGout vs. All Controls*Gout vs. HU Controls*
Sample Setrs2231142^rs10011796^Controls
N (%)
Gout
N (%)
OR (95% CI)PHU Controls
N (%)
Gout
N (%)
OR (95% CI)P
European  13,9811578  23781578  
GGCC3996 (28.6)280 (17.7)1.00601 (25.3)280 (17.7)1.00
GGCT, TT7193 (51.4)687 (43.5)1.46 (1.26–1.71)9.2E071161 (48.8)687 (43.5)1.33 (1.11–1.59)2.1E03
GT, TTCC247 (1.8)59 (3.7)3.78 (2.67–5.28)1.8E1453 (2.2)59 (3.7)2.60 (1.70–3.98)9.9E06
GT, TTCT, TT2545 (18.2)552 (35.0)3.37 (2.87–3.98)2.8E48563 (23.7)552 (35.0)2.24 (1.85–2.73)5.8E16
WP  234369  88369  
GGCC22 (9.4)14 (3.8)1.009 (10.2)14 (3.8)1.00 
GGCT, TT110 (47.0)82 (22.2)1.47 (0.63–3.54)0.3839 (44.3)82 (22.2)2.39 (0.81–6.98)0.11
GT, TTCC9 (3.8)24 (6.5)4.81 (1.53–16.06)8.5E031 (1.1)24 (6.5)21.52 (3.05–449.83)8.6E03
GT, TTCT, TT93 (39.7)249 (67.5)4.40 (1.92–10.33)5.1E0439 (44.3)249 (67.5)5.26 (1.84–14.74)1.6E03
EP  462541  114541  
GGCC77 (16.7)72 (13.3)1.0016 (14.0)72 (13.3)1.00
GGCT, TT339 (73.4)362 (66.9)0.96 (0.63–1.46)0.8585 (74.6)362 (66.9)0.83 (0.42–1.57)0.58
GT, TTCC8 (1.7)21 (3.9)2.88 (0.98–9.25)0.0642 (1.8)21 (3.9)1.44 (0.31–10.58)0.67
GT, TTCT, TT38 (8.2)86 (15.9)2.45 (1.36–4.47)3.2E0311 (9.6)86 (15.9)1.78 (0.72–4.52)0.22
  1. *European sample set adjusted by age and sex. Polynesian sample sets additionally adjusted by PCs 1–10
  2. ^The T allele (presence highlighted in bold) is the gout risk allele in European for both SNPs