Table 5 Risk of gout in rs2231142-rs10011796 genotype combinations classified by absence/presence of gout risk alleles
Genotype | Gout vs. All Controls* | Gout vs. HU Controls* | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Sample Set | rs2231142^ | rs10011796^ | Controls N (%) | Gout N (%) | OR (95% CI) | P | HU Controls N (%) | Gout N (%) | OR (95% CI) | P |
European | 13,981 | 1578 | 2378 | 1578 | ||||||
GG | CC | 3996 (28.6) | 280 (17.7) | 1.00 | – | 601 (25.3) | 280 (17.7) | 1.00 | – | |
GG | CT, TT | 7193 (51.4) | 687 (43.5) | 1.46 (1.26–1.71) | 9.2E–07 | 1161 (48.8) | 687 (43.5) | 1.33 (1.11–1.59) | 2.1E–03 | |
GT, TT | CC | 247 (1.8) | 59 (3.7) | 3.78 (2.67–5.28) | 1.8E–14 | 53 (2.2) | 59 (3.7) | 2.60 (1.70–3.98) | 9.9E–06 | |
GT, TT | CT, TT | 2545 (18.2) | 552 (35.0) | 3.37 (2.87–3.98) | 2.8E–48 | 563 (23.7) | 552 (35.0) | 2.24 (1.85–2.73) | 5.8E–16 | |
WP | 234 | 369 | 88 | 369 | ||||||
GG | CC | 22 (9.4) | 14 (3.8) | 1.00 | – | 9 (10.2) | 14 (3.8) | 1.00 | ||
GG | CT, TT | 110 (47.0) | 82 (22.2) | 1.47 (0.63–3.54) | 0.38 | 39 (44.3) | 82 (22.2) | 2.39 (0.81–6.98) | 0.11 | |
GT, TT | CC | 9 (3.8) | 24 (6.5) | 4.81 (1.53–16.06) | 8.5E–03 | 1 (1.1) | 24 (6.5) | 21.52 (3.05–449.83) | 8.6E–03 | |
GT, TT | CT, TT | 93 (39.7) | 249 (67.5) | 4.40 (1.92–10.33) | 5.1E–04 | 39 (44.3) | 249 (67.5) | 5.26 (1.84–14.74) | 1.6E–03 | |
EP | 462 | 541 | 114 | 541 | ||||||
GG | CC | 77 (16.7) | 72 (13.3) | 1.00 | – | 16 (14.0) | 72 (13.3) | 1.00 | – | |
GG | CT, TT | 339 (73.4) | 362 (66.9) | 0.96 (0.63–1.46) | 0.85 | 85 (74.6) | 362 (66.9) | 0.83 (0.42–1.57) | 0.58 | |
GT, TT | CC | 8 (1.7) | 21 (3.9) | 2.88 (0.98–9.25) | 0.064 | 2 (1.8) | 21 (3.9) | 1.44 (0.31–10.58) | 0.67 | |
GT, TT | CT, TT | 38 (8.2) | 86 (15.9) | 2.45 (1.36–4.47) | 3.2E–03 | 11 (9.6) | 86 (15.9) | 1.78 (0.72–4.52) | 0.22 | |