Table 3 Hazard ratios for SRC from a multivariable Cox proportional hazard model with an interaction of arterial hypertension and ACE inhibitors based on the medication dataset
From: ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis—a EUSTAR analysis
No. of renal crises/patients | Hazard ratio (95% CI) | P value | |
|---|---|---|---|
Age (per decade) | 78/6083 | 1.06 (0.87–1.28) | 0.58 |
Sex (male) | 1.29 (0.74–2.27) | 0.37 | |
Diffuse skin involvement | 1.78 (1.05–3.01) | 0.032 | |
Time since onset of scleroderma (per decade) | 0.77 (0.55–1.08) | 0.13 | |
Arterial hypertension | 2.41 (1.26–4.61) | 0.008 | |
Tendon friction rub | 1.70 (0.83–3.48) | 0.15 | |
ACE inhibitors | 2.28 (1.16–4.51) | 0.018 | |
SCL70-positive | 0.98 (0.58–1.67) | 0.95 | |
ACA-positive | 0.83 (0.46–1.50) | 0.53 | |
Glucocorticoids > 10 mg | 1.49 (0.53–4.17) | 0.45 | |
PDE5 inhibitors | 1.31 (0.60–2.86) | 0.50 | |
Arterial hypertension#ACE inhibitors | 0.83 (0.32–2.13) | 0.69 |