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Table 3 Hazard ratios for SRC from a multivariable Cox proportional hazard model with an interaction of arterial hypertension and ACE inhibitors based on the medication dataset

From: ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis—a EUSTAR analysis

 No. of renal crises/patientsHazard ratio (95% CI)P value
Age (per decade)78/60831.06 (0.87–1.28)0.58
Sex (male) 1.29 (0.74–2.27)0.37
Diffuse skin involvement 1.78 (1.05–3.01)0.032
Time since onset of scleroderma (per decade) 0.77 (0.55–1.08)0.13
Arterial hypertension 2.41 (1.26–4.61)0.008
Tendon friction rub 1.70 (0.83–3.48)0.15
ACE inhibitors 2.28 (1.16–4.51)0.018
SCL70-positive 0.98 (0.58–1.67)0.95
ACA-positive 0.83 (0.46–1.50)0.53
Glucocorticoids > 10 mg 1.49 (0.53–4.17)0.45
PDE5 inhibitors 1.31 (0.60–2.86)0.50
Arterial hypertension#ACE inhibitors 0.83 (0.32–2.13)0.69