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Table 5 Immunogenicity—total incidence of ADAs

From: Comparative clinical efficacy and safety of the proposed biosimilar ABP 710 with infliximab reference product in patients with rheumatoid arthritis

 

Antibody positive by week 22 with a negative or no result at baseline

Antibody positive post week 22 with a negative or no result at week 22

ABP 710

RP

ABP 710/ABP 710

RP/RP

RP/ABP 710

Number of patients

261

264

96

45

45

Binding antibody, n (%)

149 (57.1)

160 (60.6)

29 (30.2)

19 (42.2)

18 (40.0)

Neutralizing antibody, n (%)

47 (18.0)

55 (20.8)

3 (3.1)

1 (2.2)

2 (4.4)

  1. Abbreviations: ADA antidrug antibody, RP reference product