Fig. 1
From: MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1
Toluidine blue (TB) and immunohistochemical (IHC) staining images of each section are shown. a–d Results showing that severe cartilage degeneration and loss of aggrecan (ACAN) of cartilage occurred in the unilateral anterior crossbite (UAC) group compared with the NC control group. In the UAC groups, the knockout (KO) UAC group had a reversal effect on cartilage degradation and ACAN loss. Comparison of the average optical density (AOD) (b) and the thickness of cartilage (c) of TB staining between groups. e Comparison of the AOD of IHC staining for ACAN between groups. Asterisk (*): compared with the wild-type negative control (WT-NC) group. Hash (#): compared with the wild-type UAC (WT-UAC) group. Data are represented as the means ± standard deviation (n = 3). *P < 0.05, #P < 0.05. NS, not significant. Scale bar, 50 μm