Fig. 4
From: MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1
MiR-21-5p mediates the expression of related genes in IL-1β-induced condylar chondrocytes. a RT-qPCR detected the expression of miR-21-5p. b Protein expression levels of Spry1, MMP-13, VEGF and p-ERK1/2 were assayed by Western blot in MCCs under stimulation with IL-1β for 24 h. Western blotting results of Spry1, MMP-13, VEGF and p-ERK1/2 proteins in MCCs transfected with miR-21-5p mimic (c) or miR-21-5p inhibitor (d), followed by stimulation with IL-1β for 24 h. Asterisk (*): compared with mimic NC (b, d) or inhibitor NC group (c, e). Hash (#): compared with the mimic NC + IL-1β or inhibitor NC + IL-1β group. Data are represented as the means ± standard deviation (n = 3). *P < 0.05, #P < 0.05. NS, not significant