Fig. 7
From: MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1
MiR-21-5p could affect the expression of MCC inflammatory factors by regulating Spry1. a MCCs transfected with Spry1 siRNA (si-Spry1) or negative control (si-NC) were stimulated by 10 ng/ml IL-1β for 24 h. b MCCs transfected with empty vector (cDNA NC) or Spry1 ectopic expression plasmid (cDNA Spry1) for 24 h were stimulated by IL-1β for another 24 h. Asterisk (*): compared with the si-NC (a) or cDNA NC (b) group. Hash (#): compared with the si-NC + IL-1β (a) group or cDNA NC + IL-1β (b) group. Western blot analysis showing the expression of Spry1, MMP-13, VEGF and p-ERK1/2 in MCCs (a, b). Data are represented as the means ± standard deviation (n = 3). *P < 0.05, #P < 0.05. NS, not significant