Fig. 9
From: MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1
MiR-21-5p enhances the angiogenesis potential of MCCs by activating the ERK/MAPK signalling pathway. a, c MCCs were transfected with miR-21-5p mimic or miR-21-5p inhibitor and treated with U0126. a CAM representative images showing the inoculation area of the different experimental conditions. b Quantitative evaluation of the number of new blood vessels grown towards each inoculation area. Detection of VEGF protein expression changes (c). Data are represented as the means ± standard deviation (n = 8) (b). Data are represented as the means ± standard deviation (n = 3) (c). Asterisk (*): compared with the negative control (NC) group. Hash (#): compared with the mimic group. *P < 0.05, #P < 0.05. NS, not significant. Scale bar, 50 μm