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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization

Fig. 7

In vivo experiment demonstrating exosomal miR-124-3p derived from BMMSCs regulated Ern1 and polarization of M2 macrophage in SCIRI rats. a Ern1, Arg1, Ym1, and Fizz expression in rats spinal cord tissues determined using RT-qPCR. b Ern1, Arg1, Ym1, and Fizz protein levels in rat spinal cord tissues measured by western blot analysis. c Immunohistochemistry assay of Ern1, Arg1, Ym1, and Fizz expression in rat spinal cord tissues (× 400). d Immunofluorescence assay of Ern1, Arg1, Ym1, and Fizz expression in rats spinal cord tissues (× 400). *p < 0.05 versus sham operation; #p < 0.05 versus SCIRI treatment without exosome derived from BMMSCs. All measurement data were described as mean ± standard deviation. Comparison between two groups was conducted using unpaired t-test; n = 10

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Arthritis Research & Therapy

ISSN: 1478-6362

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