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Fig. 9 | Arthritis Research & Therapy

Fig. 9

From: Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization

Fig. 9

Schematic image of potential molecular mechanisms. Exosomes carrying miR-124-3p derived from BMMSCs enhance M2 macrophage polarization by regulating Ern1, thus alleviating spinal injury in SCIRI. In SCIRI rats, exosomes were derived from BMMSCs expressing miR-124-3p, which elevated Arg1, Ym1, and Fizz expression and promoted M2 macrophage polarization by inhibiting Ern1 expression. Furthermore, exosomal miR-124-3p suppressed cell apoptosis and nerve injury induced by SCIRI

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Arthritis Research & Therapy

ISSN: 1478-6362

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