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Table 1 Demographic and clinical information for the SLE cohort at baseline visit

From: The baseline interferon signature predicts disease severity over the subsequent 5 years in systemic lupus erythematosus

 

All patients, N = 137

High IFN5, N = 96

Low IFN5, N = 41

Age; mean ± SD (range)

36.4 ± 14.1 (18–76.3)

33.6 ± 12.5 (18–66.6)

43.0 ± 15.6 (18–76.3)

Female Sex; N (%)

118 (86.1)

83 (86.5)

35 (85.4)

Disease duration (years); mean ± SD (range)

10.8 ± 9.2 (0–48.5)

9.7 ± 8.3 (0–33.3)

13.3 ± 10.6 (0.1–48.5)

SLEDAI-2K; mean ± SD (range)

6.6 ± 6.3 (0–29)

7.4 ± 6.8 (0–29)

4.8 ± 4.8 (0–20)

cSLEDAI-2K; mean ± SD (range)

4.7 ± 5.6 (0–25)

5.3 ± 6.0 (0–25)

3.3 ± 4.2 (0–16)

Clinical features; N (%)

 CNS

3 (2.2)

2 (2.1)

1 (2.4)

 Vasculitis

4 (2.9)

3 (3.1)

1 (2.4)

 Arthritis

17 (13.1)

15 (15.6)

2 (4.9)

 Myositis

0 (0)

0 (0)

0 (0)

 Nephritis

52 (38.0)

35 (36.4)

17 (41.5)

 Rash

21 (15.3)

18 (18.8)

3 (7.3)

 Alopecia

22 (16.8)

18 (18.8)

4 (9.8)

 Ulcers

13 (9.5)

12 (12.5)

1 (2.4)

 Pleuritis

4 (2.9)

3 (3.1)

1 (2.4)

 Pericarditis

2 (1.5)

1 (1.0)

1 (2.4)

 Low complement

59 (43.1)

42 (43.8)

17 (41.5)

 dsDNA Abs

75 (54.7)

61 (63.5)

14 (34.1)

 Fever

5 (3.6)

4 (4.2)

1 (2.4)

 Thrombocytopenia

4 (2.9)

3 (3.1)

1 (2.4)

 Leukopenia

3 (2.2)

3 (3.1)

0 (0)

SDI; mean ± SD (range)

1.4 ± 1.6 (0–8)

1.2 ± 1.6 (0–8)

1.8 ± 1.6 (0–5)

Prednisone dose (mg); mean ± SD (range)

15.9 ± 20.7 (0–150)

16.8 ± 21.9 (0–150)

13.7 ± 17.5 (0–60)

Anti-malarials; N (%)

104 (75.9)

73 (76.0)

31 (75.6)

Immunosuppressives; N (%)

86 (62.8)

63 (65.6)

23 (56.1)

 Azathioprine

35 (25.5)

25 (26.0)

10 (24.4)

 Mycophenolate

45 (32.8)

33 (34.4)

12 (29.3)

 Methotrexate

7 (5.1)

6 (6.2)

1 (2.4)

 Cyclosporine

2 (1.5)

1 (1.0)

1 (2.4)

 Cyclophosphamide

2 (1.5)

2 (2.1)

0 (0)

 Others

1 (0.7)

1 (1.0)

0 (0)

  1. Abbreviations: SD standard deviation, N number, SLEDAI-2K SLE disease activity index-2000, cSLEDAI-2K clinical SLEDAI-2K, SDI SLE damage index