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Table 2 The common genes identified by both TWAS and microarray expression data

From: Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis

Genes

CHR

HSQ

BEST.GWAS.ID

NSNP

PTWAS

Regulation*

ANXA5e

4

0.449

rs7691220

439

0.04665

Down

AP4B1y

1

0.092

rs2476601

463

0.00849

Down

ATICt

2

0.335

rs4673928

473

0.01130

Down

C12orf65t

12

0.067

rs1727323

335

0.00191

Down

CMAHn

6

0.081

rs6906654

682

0.01422

Down

PDHBy

3

0.116

rs13315591

435

0.02839

Down

RUNX3y

1

0.044

rs4520361

372

0.03460

Down

SBF1y

22

0.115

rs5771362

303

0.01867

Down

SH2B3y

12

0.046

rs4346023

243

0.00345

Down

STK38y

6

0.089

rs7764323

567

0.00056

Down

TMEM43y

3

0.049

rs1106087

556

0.03760

Down

XPNPEP1n,y

10

0.016

rs10787226

321

0.04826

Down

KIAA1530n

4

0.189

rs3755963

345

0.00462

Up

NUFIP2n

17

0.018

rs2041156

345

0.00519

Up

PPP2R3Cn,y

14

0.060

rs10162419

384

0.00072

Up

RAB24e

5

0.369

rs4976688

299

0.03134

Up

STX6y

1

0.103

rs1538620

464

0.00116

Up

TLR5n

4

0.449

rs7691220

439

0.04665

Up

  1. CHR chromosome, HSQ heritability of the gene, BEST.GWAS.ID rsID of the most significant GWAS SNP in locus, NSNP number of SNPs in the locus, PTWAS TWAS P value. *Presents the regulation of gene in genome-wide transcriptional profiles measured on microarrays. e, t, n, yMean the genes were identified by TWAS in EL, TF, NBL, and YBL, respectively