Fig. 1From: Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implicationsThe biogenesis and general mechanisms of circRNAs. CircRNAs are generated through different ways: (1) Spliceosome mediated back-splicing and ligation; (2) Cis-elements involved circRNA biogenesis; (3) RNA-binding protein (RBP) regulated circRNA formation. Meanwhile, circRNAs may exert their functions through acting as miRNAs sponge, modulating the transcription, interplaying with protein directly, or translating into proteinBack to article page