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Table 1 regulatory roles of circRNAs in OA

From: Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications

circRNAs

model/ system

Expression

Function

Pathway

Ref

circRNA-UBE2G1

Human cartilage/ C28/I2 cell line

↑

Reducing viability and promoting apoptosis of chondrocytes

circRNA-UBE2G1/ miR-373/ HIF-1a

[80]

circ_0136474

Human cartilage/ primary articular chondrocytes

↑

Inhibiting the proliferation and promoting the apoptosis of chondrocytes

circ_0136474/ MMP-13

[24]

circRNA-CER

Human cartilage/ primary articular chondrocytes

↑

Facilitating chondrocyte ECM degradation

circRNA-CER/ miR-136/ MMP-13

[81]

circVCAN

Human cartilage/ primary articular chondrocytes

↑

Promoting chondrocytes proliferation

circVCAN/ NF-κB

[60]

circPSM3

Human cartilage/ primary articular chondrocytes

↑

Enhancing chondrocytes proliferation and differentiation

circPSM3/ miRNA-296-5p

[59]

hsa_circ_0005105

Human primary articular chondrocytes (IL-1β stimulation)

↑

Promoting ECM degradation

hsa_circ_0005105/ miR-26a/NAMPT

[25]

circRNA-CDR1as

Human cartilage/ primary articular chondrocytes

↑

Modulating ECM metabolism and inflammation of chondrocytes

circRNA-CDR1as//miR-641/FGF-2

[82]

circRNA_Atp9b

Mouse articular chondrocytes (IL-1β stimulation)

↑

Promoting ECM degradation and inflammation of chondrocytes

circRNA_Atp9b/ miR-138-5p

[83]

circRNA.33186

Mouse DMM model/ primary chondrocytes

↑

Suppressing proliferation and promoting ECM degradation

circRNA.33186/ miR-127-5p/ MMP-13

[84]

circGCN1L1

Human TMJ synovial tissue/ primary synoviocyte/ primary chondrocytes

↑

Promoting chondrocytes apoptosis and synoviocyte proliferation

circGCN1L1/ miR-330-3p/ TNF-α

[26]

circ9119

Human cartilage/ SW1353 cell line

↓

Its overexpression protects chondrocytes from apoptosis

circ9119/miR-26a/PTEN

[85]

hsa_circ_0045714

Human cartilage/ primary articular chondrocytes

↓

Its overexpression promotes ECM synesis and chondrocytes proliferation

hsa_circ_0045714/ miR-193b/ IGF-1R

[86]

circSERPINE2

Human cartilage/ Rabbit ACLT model

↓

Its downregulation promotes the apoptosis and ECM degradation

circSERPINE2/ miR-1271/ ERG

[87]

ciRS-7

Human blood sample/ C28/I2 cell line

↓

Its downregulation promotes the secretion of inflammatory cytokines

ciRS-7/ miR-7

[88]

  1. ↑upregulation, ↓downregulation, ECM extracellular matrix, ERG E26 transformation-specific (ETS)-related gene, HIF-1a hypoxia-inducible factor-1a, IGF-1R insulin-like growth factor 1 receptor, MMP-13 matrix metalloproteinase 13, NAMPT nicotinamide phosphoribosyl transferase