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Table 1 regulatory roles of circRNAs in OA

From: Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications

circRNAs model/ system Expression Function Pathway Ref
circRNA-UBE2G1 Human cartilage/ C28/I2 cell line Reducing viability and promoting apoptosis of chondrocytes circRNA-UBE2G1/ miR-373/ HIF-1a [80]
circ_0136474 Human cartilage/ primary articular chondrocytes Inhibiting the proliferation and promoting the apoptosis of chondrocytes circ_0136474/ MMP-13 [24]
circRNA-CER Human cartilage/ primary articular chondrocytes Facilitating chondrocyte ECM degradation circRNA-CER/ miR-136/ MMP-13 [81]
circVCAN Human cartilage/ primary articular chondrocytes Promoting chondrocytes proliferation circVCAN/ NF-κB [60]
circPSM3 Human cartilage/ primary articular chondrocytes Enhancing chondrocytes proliferation and differentiation circPSM3/ miRNA-296-5p [59]
hsa_circ_0005105 Human primary articular chondrocytes (IL-1β stimulation) Promoting ECM degradation hsa_circ_0005105/ miR-26a/NAMPT [25]
circRNA-CDR1as Human cartilage/ primary articular chondrocytes Modulating ECM metabolism and inflammation of chondrocytes circRNA-CDR1as//miR-641/FGF-2 [82]
circRNA_Atp9b Mouse articular chondrocytes (IL-1β stimulation) Promoting ECM degradation and inflammation of chondrocytes circRNA_Atp9b/ miR-138-5p [83]
circRNA.33186 Mouse DMM model/ primary chondrocytes Suppressing proliferation and promoting ECM degradation circRNA.33186/ miR-127-5p/ MMP-13 [84]
circGCN1L1 Human TMJ synovial tissue/ primary synoviocyte/ primary chondrocytes Promoting chondrocytes apoptosis and synoviocyte proliferation circGCN1L1/ miR-330-3p/ TNF-α [26]
circ9119 Human cartilage/ SW1353 cell line Its overexpression protects chondrocytes from apoptosis circ9119/miR-26a/PTEN [85]
hsa_circ_0045714 Human cartilage/ primary articular chondrocytes Its overexpression promotes ECM synesis and chondrocytes proliferation hsa_circ_0045714/ miR-193b/ IGF-1R [86]
circSERPINE2 Human cartilage/ Rabbit ACLT model Its downregulation promotes the apoptosis and ECM degradation circSERPINE2/ miR-1271/ ERG [87]
ciRS-7 Human blood sample/ C28/I2 cell line Its downregulation promotes the secretion of inflammatory cytokines ciRS-7/ miR-7 [88]
  1. ↑upregulation, ↓downregulation, ECM extracellular matrix, ERG E26 transformation-specific (ETS)-related gene, HIF-1a hypoxia-inducible factor-1a, IGF-1R insulin-like growth factor 1 receptor, MMP-13 matrix metalloproteinase 13, NAMPT nicotinamide phosphoribosyl transferase