Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative

Table 2 Cross-sectional associations between OA-related MRI features and weight-bearing pain

	Spearman’s r	p	Β₁ (95% CI)	p	Β₂ (95% CI)	p
Total BML score	0.34	< 0.001**	0.08 (0.04–0.11)	< 0.001**	0.07 (0.02–0.11)	0.005**
Medial FT joint	0.29	< 0.001**	0.10 (0.04–0.16)	0.001**	0.08 (0.02–0.16)	0.02*
Lateral FT joint	0.09	0.003**	−0.01 (− 0.18–0.15)	0.87	− 0.03 (− 0.19–0.14)	0.74
Medial PF joint	0.03	0.35	0.06 (− 0.06–0.17)	0.32	0.06 (− 0.06–0.18)	0.31
Lateral PF joint	0.13	< 0.001**	0.14 (0.05–0.23)	0.003**	0.13 (0.03–0.23)	0.01*
Subspinous region	0.18	< 0.001**	−0.04 (− 0.21–0.14)	0.69	− 0.06 (− 0.24–0.12)	0.53
Articular cartilage score	0.32	< 0.001**	0.05 (0.01–0.1)	0.03*	0.02 (− 0.01–0.05)	0.25
Osteophytes score	0.26	< 0.001**	0.04 (0.01–0.07)	0.01*	0.01 (− 0.01–0.03)	0.46
Hoffa’s synovitis score	0.18	< 0.001**	0.3 (0.03–0.60)	0.03*	−0.03 (− 0.21–0.15)	0.72
Effusion score	0.24	< 0.001**	0.4 (0.13–0.59)	0.002**	0.08 (−0.06–0.22)	0.26
Medial meniscus extrusion score	0.22	< 0.001**	0.15 (−0.05–0.36)	0.14	0.03 (−0.12–0.13)	0.96

B₁: OA-related MRI features adjusted for non-weight-bearing pain, age, sex, and BMI. BML subscores were in addition adjusted for BML at the other four joint compartments. B₂: OA-related MRI features adjusted for non-weight-bearing pain, age, sex, BMI, the other OA-related MRI features, and anterior cruciate ligament tears. BML subscores were in addition adjusted for BML at the other four joint compartments.*p < 0.05, ** p < 0.01
BML bone marrow lesion, FT femorotibial, PF patellofemoral

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