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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: A bioavailable form of curcumin, in combination with vitamin-D- and omega-3-enriched diet, modifies disease onset and outcomes in a murine model of collagen-induced arthritis

Fig. 6

Combination of CUR and VO-enriched enhanced suppression of TNF, IFN-γ, and MCP-1, compared to either CUR or VO-enriched diet alone, in CIA mice. Saline control and CIA mice under different conditions as indicated were euthanized by cardiac puncture under anesthesia on day 29 after the first CII challenge. Concentrations of a panel of 29 cytokines/cytokines were examined in serum, using the V-PLEX mouse multiplex Meso Scale Discovery (MSD) assay kit. Volcano plots shown represent log2 transformed intensity values for each analyte, between two groups of CIA mice a on the normal diet, with and without CUR administration, b fed normal diet with those on VO-enriched diet, c on normal diet with those fed VO-enriched diet and CUR administration, and d CUR administration, on normal diet with those fed the VO-enriched diet. Cytokines shown in red are those with > 2-fold change (p < 0.01)

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Arthritis Research & Therapy

ISSN: 1478-6362

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