A bioavailable form of curcumin, in combination with vitamin-D- and omega-3-enriched diet, modifies disease onset and outcomes in a murine model of collagen-induced arthritis

Table 3 Percent decrease of cytokines and chemokines in serum

Cytokine	% Decrease compared to mean abundance in CIA mice on normal diet
	CIA + CUR		CIA + VO		CIA + VO + CUR
	% Decrease	p value	% Decrease	p value	% Decrease	p value
IFNγ	58 ± 7.3	p < 0.0003	55 ± 4.1	p < 0.0003	82 ± 3.3	p < 0.0001
TNF	45 ± 3.6	p < 0.0002	36 ± 2.3	p < 0.0002	69 ± 2.8	p < 0.0002
IL-1β	73 ± 2.6	p < 0.001	34 ± 5.3	p < 0.0015	75 ± 3.1	p < 0.0001
IL-6	77 ± 2.7	p < 0.002	16 ± 8.4	p < 0.211	77 ± 3.0	p < 0.002
IL-33	76 ± 4.8	p < 0.004	70 ± 4.8	p < 0.001	61 ± 6.8	p < 0.005
IL-15	75 ± 6.6	p < 0.0003	91 ± 2.5	p < 0.097	81 ± 2.9	p < 0.0003
IL-16	47 ± 6.3	p < 0.0005	20 ± 6.2	p < 0.0002	60 ± 3.4	p < 0.0002
IL-10	46 ± 6.3	p < 0.041	37 ± 3.7	p < 0.002	51 ± 4.4	p < 0.0002
MCP-1	36 ± 5.9	p < 0.0003	22 ± 2.9	p < 0.021	55 ± 3.1	p < 0.0003
KC/GRO	54 ± 8.2	p < 0.0002	16 ± 8.0	p < 0.112	67 ± 3.8	p < 0.0002
IP-10	59 ± 4.9	p < 0.001	40 ± 1.9	p < 0.001	62 ± 3.9	p < 0.0001
MIP-1α	38 ± 5.8	p < 0.001	30 ± 4.8	p < 0.031	59 ± 3.4	p < 0.0015

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