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Table 1 Clinical and ultrasound data for the patients in DAS28CRP-remission > 1 year obtained through a treat-to-target steered strategy

From: Using a DAS28-CRP-steered treat-to-target strategy does not eliminate subclinical inflammation as assessed by ultrasonography in rheumatoid arthritis patients in longstanding clinical remission

 

All patients (n = 87)

csDMARD group (n = 45)

bDMARD group (n = 42)

Difference between groups (p values)

Age (years)

61 (25–82)

64 (31–82)

57 (25–82)

0.14

Female gender

66%

62%

69%

0.50

Disease duration (years)

10 (1–54)

6 (1–44)

13 (0–2)

< 0.001

Positive rheumatoid factor

61%

56%

67%

0.29

Positive anti-CCP

67%

56%

79%

0.02

Erosive disease

66%

51%

81%

0.003

Number of current DMARDs

1 (0–3)

1 (0–3)

1 (0–1)

0.003

Clinical assessment

 Swollen joint count (0–28)

0 (0–2)

0 (0–2)

0 (0–2)

0.71

 Tender joint count (0–28)

0 (0–1)

0 (0–1)

0 (0–1)

0.60

 CRP (mg/L)

5 (1–26)

4 (1–13)

5 (4–26)

< 0.001

 DAS28CRP

1.8 (1.1–2.5)

1.7 (1.1–2.4)

1.9 (1.6–2.5)

0.002

 HAQ (0–3)

0.125 (0–1.625)

0 (0–0.875)

0.31 (0–1.625)

0.002

 VAS Global (mm) (0–100)

13 (0–67)

10 (0–45)

15 (0–67)

0.16

 ACR-EULAR*

1.6 (0–7.7)

1.4 (0–5.3)

1.8 (0–7.7)

0.35

 ACR-EULAR-remission*

77%

76%

79%

0.74

 SDAI

2.1 (0.3–8.2)

1.6 (0.3–6.1)

2.8 (0.5–8.2)

0.05

 SDAI-remission

75%

76%

74%

0.85

Ultrasound assessment

 Grey-scale sum score (0–72)

6 (0–19)

4 (1–18)

6.5 (0–19)

0.71

 Doppler sum score (0–72)

0 (0–12)

0 (0–12)

0 (0–7)

1.00

 Grey-scale sum score (MCP2–5 and wrist) (0–30)

3 (0–18)

3 (0–18)

3 (0–12)

0.25

 Doppler sum score (MCP2–5 and wrist) (0–30)

0 (0–12)

0 (0–12)

0 (0–5)

0.84

  1. Values are given as median (range) and percentage. Comparison between groups by Mann-Whitney’s test and Pearson chi-square with p < 0.05 considered significant
  2. DMARDs disease-modifying anti-rheumatic drugs, CRP C-reactive protein, HAQ Health Assessment Questionnaire, VAS visual analogue scale
  3. *Patients in ACR-EULAR Boolean-remission are identical to patients in CDAI-remission