Etanercept (EMBARK) N = 163a | Control (DESIR) N = 76a | P value | Control (DESIR) excludedb N = 22 | |
---|---|---|---|---|
Age, y | 31.7 (7.9) | 31.7 (7.5) | 0.94c | 31.9 (6.7) |
Male, n/N (%) | 105/163 (64.4) | 45/76 (59.2) | 0.44d | 12/22 (54.5) |
Symptom duration, years | 2.4 (1.8) | 1.5 (0.9) | < 0.001c | 1.5 (0.9) |
Current smoker, n/N (%) | 37/163 (22.7) | 29/75 (38.7) | 0.01d | 5/22 (22.7) |
HLA-B27(+), n/N (%) | 121/157 (77.1) | 66/76 (86.8) | 0.08d | 17/22 (77.3) |
BASDAI (0–10) | 6.0 (1.8) | 3.4 (2.0) | < 0.001c | 4.5 (2.1) |
ASDAS | 3.0 (1.0) | 2.1 (0.9) | < 0.001c | 2.6 (0.9) |
BASFI (0–10 cm VAS) | 4.1 (2.4) | 2.0 (1.9) | < 0.001c | 3.1 (2.9) |
CRP, mg/L | 7.4 (11.5) | 6.0 (8.1) | 0.19c | 7.1 (13.0) |
Erosion SSS (0–40)f | 2.2 (3.0) | 2.8 (3.5) | 0.12c | 0.6 (1.5), 2.4 (4.7), 1.5 (2.6) |
Backfill SSS (0–20) | 0.5 (1.3) | 0.3 (0.7) | 0.50c | NA |
Fat metaplasia SSS (0–40)f | 0.6 (1.7) | 0.5 (1.8) | 0.91c | 1.5 (3.2), 1.8 (3.7), 1.7 (3.9) |
Ankylosis SSS (0–20)f | 0.3 (1.3) | 0.2 (1.1) | 0.11c | 0.1 (0.6), 0.1 (0.3), 0.2 (0.7) |
SPARCC MRI SIJ inflammation score (0–72)f | 8.5 (11.0) | 6.0 (9.4) | 0.003c | 4.5 (6.5), 3.3 (4.0), 2.7 (3.9) |
SPARCC MRI SIJ inflammation score ≥ 2, n/N (%)f | 99/161 (61.5) | 33/76 (43.4) | 0.009d | 11/20 (55.0), 9/19 (47.4), 9/21 (42.9) |
Total SIJ score (mNY grade 0–8)f | 1.5 (1.3) | 1.6 (1.6) | 0.76c | 1.5 (2.2), 1.4 (2.0), 1.7 (1.6) |
SIJ radiograph met mNY criteria (%)e, f | 19/156 (12.2) | 10/68 (14.7) | 0.61d | 7/22 (31.8), 5/20 (25.0), 4/21 (19.0) |