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Table 1 Demographics and baseline disease characteristics

From: Structural changes in the sacroiliac joint on MRI and relationship to ASDAS inactive disease in axial spondyloarthritis: a 2-year study comparing treatment with etanercept in EMBARK to a contemporary control cohort in DESIR

 

Etanercept (EMBARK)

N = 163a

Control (DESIR)

N = 76a

P value

Control (DESIR) excludedb

N = 22

Age, y

31.7 (7.9)

31.7 (7.5)

0.94c

31.9 (6.7)

Male, n/N (%)

105/163 (64.4)

45/76 (59.2)

0.44d

12/22 (54.5)

Symptom duration, years

2.4 (1.8)

1.5 (0.9)

< 0.001c

1.5 (0.9)

Current smoker, n/N (%)

37/163 (22.7)

29/75 (38.7)

0.01d

5/22 (22.7)

HLA-B27(+), n/N (%)

121/157 (77.1)

66/76 (86.8)

0.08d

17/22 (77.3)

BASDAI (0–10)

6.0 (1.8)

3.4 (2.0)

< 0.001c

4.5 (2.1)

ASDAS

3.0 (1.0)

2.1 (0.9)

< 0.001c

2.6 (0.9)

BASFI (0–10 cm VAS)

4.1 (2.4)

2.0 (1.9)

< 0.001c

3.1 (2.9)

CRP, mg/L

7.4 (11.5)

6.0 (8.1)

0.19c

7.1 (13.0)

Erosion SSS (0–40)f

2.2 (3.0)

2.8 (3.5)

0.12c

0.6 (1.5), 2.4 (4.7), 1.5 (2.6)

Backfill SSS (0–20)

0.5 (1.3)

0.3 (0.7)

0.50c

NA

Fat metaplasia SSS (0–40)f

0.6 (1.7)

0.5 (1.8)

0.91c

1.5 (3.2), 1.8 (3.7), 1.7 (3.9)

Ankylosis SSS (0–20)f

0.3 (1.3)

0.2 (1.1)

0.11c

0.1 (0.6), 0.1 (0.3), 0.2 (0.7)

SPARCC MRI SIJ inflammation score (0–72)f

8.5 (11.0)

6.0 (9.4)

0.003c

4.5 (6.5), 3.3 (4.0), 2.7 (3.9)

SPARCC MRI SIJ inflammation score ≥ 2, n/N (%)f

99/161 (61.5)

33/76 (43.4)

0.009d

11/20 (55.0), 9/19 (47.4), 9/21 (42.9)

Total SIJ score (mNY grade 0–8)f

1.5 (1.3)

1.6 (1.6)

0.76c

1.5 (2.2), 1.4 (2.0), 1.7 (1.6)

SIJ radiograph met mNY criteria (%)e, f

19/156 (12.2)

10/68 (14.7)

0.61d

7/22 (31.8), 5/20 (25.0), 4/21 (19.0)

  1. aPatients with week 104 MRI data
  2. bNot included in the analysis because a week 104 MRI was not available. Included in the table for comparison only
  3. cWilcoxon rank-sum
  4. dMantel-Haenszel
  5. eRadiographs from EMBARK and DESIR cohorts were assessed by 3 central readers who were not the same readers that conducted assessment of radiographs at screening for inclusion in the EMBARK trial
  6. fFor the patients from DESIR who were excluded from this analysis, we have included 3 scores because there were 3 sets of central readers in 3 independent reading campaigns
  7. Values are mean (standard deviation) unless otherwise noted
  8. ASDAS Ankylosing Spondylitis Disease Activity Score, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, BASFI Bath Ankylosing Spondylitis Functional Index, CRP C-reactive protein, HLA human leukocyte antigen, mNY modified New York, NA not available, SPARCC MRI SIJ inflammation score Spondyloarthritis Research Consortium of Canada Magnetic Resonance Imaging Sacroiliac Joint score (a score of MRI bone marrow edema), SSS SIJ Structural Score, VAS visual analog scale