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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: The spectrum of association in HLA region with rheumatoid arthritis in a diverse Asian population: evidence from the MyEIRA case-control study

Fig. 1

Association plots of the tested variants in the HLA region to ACPA-positive RA in Malays. Legends: a Regional plot of stepwise logistic regression in ACPA-positive Malay RA patients, HLA-DRB1 Val11 mapped as the strongest association signal (PGWAS = 2.4 × 10−35). b Conditioning of HLA-DRB1 Val11, HLA-DQB1*03:02 alleles (PGWAS = 1.57 × 10−9) were mapped as the second independent HLA risk variants with decreased risk of developing ACPA-positive RA. c No independent variants observed from conditioning the two most associated HLA variants, i.e., HLA-DRB1 Val11 and HLA-DQB1*03:02 allele. The red line represents the suggested significant threshold, i.e., genome-wide significant threshold of PGWAS < 5 × 10−8

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Arthritis Research & Therapy

ISSN: 1478-6362

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