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Table 4 HLA-DRB1 amino acid haplotypes and risk of ACPA-positive RA in different populations

From: The spectrum of association in HLA region with rheumatoid arthritis in a diverse Asian population: evidence from the MyEIRA case-control study

HLA-DRB1 amino acid at position

Malay#

Chinese#

Indian#

Europeana

Europeanb

East Asianc

Classical HLA-DRB1 alleles

11

13

71

74

OR

95% CI

OR

95% CI

OR

95% CI

OR

95% CI

OR

95% CI

OR

95% CI

 

Pro

Arg

Ala

Ala

Ref

 

Ref

–

Ref

 

Ref

 

Ref

 

Ref

 

*15:01, *15:02, *15:04, *16:02

Val

His

Arg

Ala

5.28

3.06–9.09

10.33

4.39–24.31

3.84

1.02–14.44

4.22

3.75–4.75

3.63

3.29–4.01

3.02

2.62–3.48

*04:04, *04:05, *04:10

Val

Phe

Arg

Ala

4.35

2.27–8.32

–

–

2.00

1.10–3.68

4.65

3.80–5.70

2.83

2.22–3.61

*10:01

Ser

Ser

Glx

Ala

0.36

0.11–1.22

12.91

2.55–65.34

0.40

0.18–0.86

0.59

0.51–0.68

0.60

0.54–0.67

0.6

0.50–0.72

*13:01, *13:02

Ser

Ser

Lys

Arg

0.64

0.30–1.37

0.81

0.27–2.40

0.82

0.37–1.78

0.63

0.54–0.73

0.67

0.60–0.76

0.71

0.53–0.96

*03:01

Gly

Tyr

Arg

Gln

0.78

0.46–1.34

1.61

0.28–9.41

0.74

0.42–1.30

0.91

0.80–1.03

0.92

0.83–1.02

0.9

0.75–1.08

*07:01

Ser

Gly

Arg

Ala

0.83

0.57–1.22

1.67

0.76–3.66

1.28

0.50–3.30

0.88

0.77–1.00

1.04

0.86–1.25

1.12

0.95–1.32

*12:01, *12:02, *12:03

Ser

Ser

Arg

Ala

0.72

0.29–1.81

2.69

1.02–7.07

0.56

0.22–1.41

0.76

0.67–0.86

0.83

0.68–1.02

*1101, *11:05, *13:12

Val

His

Arg

Glx

0.72

0.29–1.81

1.88

0.66–5.38

1.09

0.57–2.07

1.65

1.24–2.19

1.29

1.06–1.57

0.95

0.79–1.13

*0403, *04:06

Ser

Gly

Arg

Glx

1.08

0.49–2.39

1.21

0.30–4.96

0.72

0.38–1.37

–

–

0.49

0.26–0.91

0.56

0.42–0.74

*14:04

Ser

Gly

Arg

Leu

–

–

1.41

0.51–3.87

0.87

0.25–3.00

0.71

0.57–0.89

0.83

0.70–0.98

0.85

0.72–1.01

*08:01, *08:02, *08:03, *08:09

Ser

Ser

Arg

Glx

–

–

1.34

0.43–4.24

–

–

0.84

0.67–1.05

0.77

0.64–0.94

0.77

0.60–0.99

*14:01, *14:05,*14:07

Ser

Ser

Arg

Leu

–

–

1.41

0.51–3.87

–

–

–

–

–

–

–

–

*14:03

Val

His

Lys

Ala

–

–

–

–

1.92

0.67–5.51

4.44

4.02–4.91

4.03

3.72–4.37

3.63

2.63–5.00

*04:01

Leu

Phe

Arg

Ala

–

–

–

–

–

–

2.17

1.94–2.42

2.11

1.94–2.31

1.51

1.26–1.80

*01:01, *01:02

Asp

Phe

Arg

Glx

–

–

–

–

–

–

1.65

1.29–2.10

1.82

1.52–2.18

1.8

1.56–2.09

*09:01

Pro

Arg

Arg

Ala

–

–

–

–

–

–

2.04

1.59–2.62

1.58

1.26–1.99

1.21

0.85–1.73

*16:01, *16:02

Val

His

Glx

Ala

–

–

–

–

–

–

1.43

1.04–1.96

1.03

0.71–1.50

–

–

*04:02, *04:37

Ser

Ser

Lys

Ala

–

–

–

–

–

–

1.04

0.76–1.41

0.87

0.66–1.14

–

–

*13:03

Leu

Phe

Glx

Ala

–

–

–

–

–

–

0.73

0.42–1.27

0.71

0.55–0.93

–

–

*01:03

  1. ACPA anti-citrullinated protein antibody, HLA human leukocyte antigen, DRB1 DR beta chain 1, OR odds ratio, 95% CI 95% confidence interval. Amino acid abbreviations: Pro proline, Arg arginine, Ala alanine, Val valine, His histidine, Phe phenylalanine, Ser serine, Glx glutamic acid/glutamine, Gly glycine, Tyr tyrosine, Gln glutamine, Leu leucine, Lys lysine. #The individuals with Malay, Chinese, and Indian ethnicity recruited for Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) population-based case-control study. aPublished data retrieved from Raychaudhuri et al. [17]. bPublished data retrieved from Han et al. (2014) [21]. cPublished data retrieved from Okada et al. (2014) [37]
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Arthritis Research & Therapy

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