From: Serum complement 3 is a potential biomarker for assessing disease activity in Takayasu arteritis
Total (n = 519) | Inactive (n = 113) | Active (n = 406) | P value | |
---|---|---|---|---|
Age, years | 32.0 (24.0–45.0) | 32.0 (23.0–44.0) | 32.0 (24.0–46.0) | 0.585 |
Female, n (%) | 427 (82.3) | 89 (78.8) | 338 (83.3) | 0.269 |
Course, months | 21.0 (4.0–70.5) | 20.5 (5.0–60.0) | 23.0 (3.0–71.0) | 0.909 |
Symptoms | ||||
Fever, n (%) | 71 (13.7) | 12 (11.3) | 59 (14.8) | 0.366 |
Fatigue, n (%) | 173 (33.3) | 29 (25.7) | 144 (35.5) | 0.011* |
Night sweat, n (%) | 16 (3.1) | 0 (0) | 16 (4.0) | 0.030* |
Dizziness, n (%) | 215 (41.4) | 44 (41.9) | 171 (43.0) | 0.845 |
Neck pain, n (%) | 40 (7.7) | 6 (5.6) | 34 (8.5) | 0.316 |
Chest pain, n (%) | 115 (22.2) | 15 (14.2) | 100 (24.9) | 0.018* |
Abdominal pain, n (%) | 14 (2.7) | 0 (0) | 14 (3.5) | 0.048* |
Signs | ||||
Pulseless, n (%) | 217 (41.8) | 33 (29.2) | 184 (45.3) | 0.034* |
Vascular bruit, n (%) | 231 (44.5) | 24 (24.0) | 207 (52.3) | < 0.001* |
ESR, mm/H | 33.0 (14.0–59.0) | 15.0 (7.0–23.0) | 40.0 (18.0–66.5) | < 0.001* |
Vascular stenosis, n (%) | 426 (82.1) | 82 (72.6) | 344 (84.7) | 0.882 |
Vascular thickening, n (%) | 280 (53.9) | 40 (35.4) | 240 (59.1) | 0.001* |
Type, n (%) | ||||
I | 148 (28.5) | 32 (28.3) | 116 (28.6) | |
IIa | 37 (7.1) | 9 (8.0) | 28 (6.9) | |
IIb | 40 (7.7) | 2 (1.8) | 38 (9.4) | |
III | 20 (3.9) | 5 (4.4) | 15 (3.7) | |
IV | 53 (10.2) | 15 (13.2) | 38 (9.4) | |
V | 182 (35.1) | 31 (27.4) | 151 (37.2) | 0.063 |
Hypertension, n (%) | 111 (21.4) | 26 (23.0) | 85 (20.9) | 0.145 |
Hyperlipidemia, n (%) | 13 (2.5) | 4 (3.5) | 9 (2.2) | 0.261 |
Haemoglobin, g/L | 118.5 (106.0–130.0) | 124.0 (115.0–133.0) | 117.0 (105.0–129.0) | < 0.001* |
WBC, × 109/L | 7.5 (6.0–9.8) | 7.3 (6.0–8.8) | 7.5 (6.0–9.9) | 0.325 |
Platelet, × 109/L | 265.0 (213.0–342.0) | 250.0 (210.0–302.5) | 275.0 (213.5–353.0) | 0.048* |
Albumin, g/L | 40.0 (37.0–43.0) | 42.0 (39.0–44.2) | 39.0 (36.2–42.1) | < 0.001* |
Globin, g/L | 29.0 (26.0–34.0) | 27.0 (24.0–33.0) | 30.0 (26.0–35.0) | < 0.001* |
Creatinine, μmol/L | 58.0 (49.0–70.0) | 60.0 (50.0–73.0) | 57.5 (49.0–69.0) | 0.564 |
Immunity-related markers | ||||
CRP, mg/L | 7.5 (1.9–30.6) | 2.4 (0.8–8.0) | 10.8 (2.4–39.1) | < 0.001* |
TNF-α, pg/mL | 7.7 (5.8–10.2) | 7.2 (5.9–10.1) | 7.9 (5.8–10.30 | 0.692 |
IL-6, pg/mL | 5.3 (2.4–11.2) | 3.7 (2.1–7.4) | 5.7 (2.7–12.3) | 0.010* |
C3, g/L | 1.15 (0.99–1.33) | 1.00 (0.91–1.15) | 1.19 (1.03–1.56) | < 0.001* |
C4, g/L | 0.24 (0.20–0.29) | 0.22 (0.19–0.27) | 0.25 (0.20–0.30) | 0.040* |
CH50, g/L | 65.2 ± 18.2 | 59.3 ± 17.9 | 66.4 ± 18.1 | 0.015* |
IgG, g/L | 13.1 (10.5–16.3) | 11.7 (9.4–13.8) | 13.3 (10.8–6.6) | 0.002* |
IgA, g/L | 2.6 (1.8–3.6) | 2.3 (1.7–3.0) | 2.6 (1.9–3.8) | 0.013* |
IgM, g/L | 1.4 (1.1–2.0) | 1.4 (1.0–1.8) | 1.5 (1.1–2.0) | 0.160 |
IgE, g/L | 26.0 (13.0–82.3) | 25.0 (12.0–70.0) | 26.0 (13.0–84.5) | 0.982 |
Medication history | ||||
Prednisone, n (%) | 78 (15.0) | 15 (13.3) | 63 (15.5) | 0.502 |
Methotrexate, n (%) | 11 (2.1) | 0 (0) | 11 (2.7) | 0.134 |
Cyclophosphamide, n (%) | 58 (11.2) | 17 (15.0) | 41 (10.1) | 0.157 |