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Table 1 The characteristics of TA patients in different disease activity status

From: Serum complement 3 is a potential biomarker for assessing disease activity in Takayasu arteritis

 

Total (n = 519)

Inactive (n = 113)

Active (n = 406)

P value

Age, years

32.0 (24.0–45.0)

32.0 (23.0–44.0)

32.0 (24.0–46.0)

0.585

Female, n (%)

427 (82.3)

89 (78.8)

338 (83.3)

0.269

Course, months

21.0 (4.0–70.5)

20.5 (5.0–60.0)

23.0 (3.0–71.0)

0.909

Symptoms

 Fever, n (%)

71 (13.7)

12 (11.3)

59 (14.8)

0.366

 Fatigue, n (%)

173 (33.3)

29 (25.7)

144 (35.5)

0.011*

 Night sweat, n (%)

16 (3.1)

0 (0)

16 (4.0)

0.030*

 Dizziness, n (%)

215 (41.4)

44 (41.9)

171 (43.0)

0.845

 Neck pain, n (%)

40 (7.7)

6 (5.6)

34 (8.5)

0.316

 Chest pain, n (%)

115 (22.2)

15 (14.2)

100 (24.9)

0.018*

 Abdominal pain, n (%)

14 (2.7)

0 (0)

14 (3.5)

0.048*

Signs

 Pulseless, n (%)

217 (41.8)

33 (29.2)

184 (45.3)

0.034*

 Vascular bruit, n (%)

231 (44.5)

24 (24.0)

207 (52.3)

< 0.001*

ESR, mm/H

33.0 (14.0–59.0)

15.0 (7.0–23.0)

40.0 (18.0–66.5)

< 0.001*

Vascular stenosis, n (%)

426 (82.1)

82 (72.6)

344 (84.7)

0.882

Vascular thickening, n (%)

280 (53.9)

40 (35.4)

240 (59.1)

0.001*

Type, n (%)

 I

148 (28.5)

32 (28.3)

116 (28.6)

 

 IIa

37 (7.1)

9 (8.0)

28 (6.9)

 

 IIb

40 (7.7)

2 (1.8)

38 (9.4)

 

 III

20 (3.9)

5 (4.4)

15 (3.7)

 

 IV

53 (10.2)

15 (13.2)

38 (9.4)

 

 V

182 (35.1)

31 (27.4)

151 (37.2)

0.063

 Hypertension, n (%)

111 (21.4)

26 (23.0)

85 (20.9)

0.145

 Hyperlipidemia, n (%)

13 (2.5)

4 (3.5)

9 (2.2)

0.261

 Haemoglobin, g/L

118.5 (106.0–130.0)

124.0 (115.0–133.0)

117.0 (105.0–129.0)

< 0.001*

 WBC, × 109/L

7.5 (6.0–9.8)

7.3 (6.0–8.8)

7.5 (6.0–9.9)

0.325

 Platelet, × 109/L

265.0 (213.0–342.0)

250.0 (210.0–302.5)

275.0 (213.5–353.0)

0.048*

 Albumin, g/L

40.0 (37.0–43.0)

42.0 (39.0–44.2)

39.0 (36.2–42.1)

< 0.001*

 Globin, g/L

29.0 (26.0–34.0)

27.0 (24.0–33.0)

30.0 (26.0–35.0)

< 0.001*

 Creatinine, μmol/L

58.0 (49.0–70.0)

60.0 (50.0–73.0)

57.5 (49.0–69.0)

0.564

Immunity-related markers

 CRP, mg/L

7.5 (1.9–30.6)

2.4 (0.8–8.0)

10.8 (2.4–39.1)

< 0.001*

 TNF-α, pg/mL

7.7 (5.8–10.2)

7.2 (5.9–10.1)

7.9 (5.8–10.30

0.692

 IL-6, pg/mL

5.3 (2.4–11.2)

3.7 (2.1–7.4)

5.7 (2.7–12.3)

0.010*

 C3, g/L

1.15 (0.99–1.33)

1.00 (0.91–1.15)

1.19 (1.03–1.56)

< 0.001*

 C4, g/L

0.24 (0.20–0.29)

0.22 (0.19–0.27)

0.25 (0.20–0.30)

0.040*

 CH50, g/L

65.2 ± 18.2

59.3 ± 17.9

66.4 ± 18.1

0.015*

 IgG, g/L

13.1 (10.5–16.3)

11.7 (9.4–13.8)

13.3 (10.8–6.6)

0.002*

 IgA, g/L

2.6 (1.8–3.6)

2.3 (1.7–3.0)

2.6 (1.9–3.8)

0.013*

 IgM, g/L

1.4 (1.1–2.0)

1.4 (1.0–1.8)

1.5 (1.1–2.0)

0.160

 IgE, g/L

26.0 (13.0–82.3)

25.0 (12.0–70.0)

26.0 (13.0–84.5)

0.982

Medication history

 Prednisone, n (%)

78 (15.0)

15 (13.3)

63 (15.5)

0.502

 Methotrexate, n (%)

11 (2.1)

0 (0)

11 (2.7)

0.134

 Cyclophosphamide, n (%)

58 (11.2)

17 (15.0)

41 (10.1)

0.157

  1. ESR erythrocyte sedimentation rate, WBC white blood cells, CRP C-reactive protein, TNF-α tumour necrosis factor-α, IL-6 interleukin-6, C3 complement 3, C4 complement 4, CH50 median hemolytic complement, IgA immunoglobin A, IgG immunoglobin G, IgM immunoglobin M, IgE immunoglobin E
  2. *P < 0.05