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Table 2 The sensitivity and specificity of different biomarkers to distinguish the TA disease activity

From: Serum complement 3 is a potential biomarker for assessing disease activity in Takayasu arteritis

Marker AUC Cut-off value Sen Spe PLR NLR PPV NPV
ESR* 0.766 (0.698–0.800) 26.5 0.638 0.731 2.371 0.495 0.923 0.780
C3 0.715(0.650–0.781) 1.085 0.699 0.667 2.099 0.451 0.911 0.667
CRP 0.703(0.647–0.760) 10.65 0.507 0.824 2.881 0.598 0.923 0.824
Globin 0.658(0.600–0.716) 29.05 0.543 0.736 2.057 0.621 0.890 0.736
Albumin# 0.623(0.556–0.690) 40.25 0.667 0.581 1.592 0.573 0.721 0.345
Haemoglobin# 0.620(0.559–0.681) 120.95 0.642 0.583 1.540 0.614 0.723 0.358
IgG 0.617(0.549–0.685) 13.32 0.503 0.736 1.905 0.675 0.895 0.736
CH50 0.614(0.529–0.699) 60 0.663 0.574 1.556 0.587 0.873 0.574
IL-6 0.610(0.533–0.686) 8.85 0.38 0.817 2.077 0.759 0.776 0.817
IgA 0.592(0.524–0.661) 2.865 0.438 0.743 1.704 0.756 0.881 0.743
PLT 0.566(0.506–0.627) 274.5 0.504 0.663 1.496 0.748 0.860 0.663
Parallel test
 ESR + C3 0.683(0.600–0.767)   0.891 0.488 1.740 0.223 0.884 0.615
 CRP + C3 0.703(0.623–0.782)   0.851 0.550 1.891 0.271 0.895 0.670
 ESR + CRP 0.713(0.638–0.788)   0.822 0.602 2.066 0.296 0.901 0.710
Serial test
 ESR + C3 0.758(0.700–0.816)   0.446 0.910 4.956 0.609 0.982 0.964
 CRP + C3 0.703(0.639–0.766)   0.354 0.941 6.000 0.687 0.963 0.912
 ESR + CRP 0.699(0.631–0.738)   0.323 0.953 6.832 0.710 0.960 0.918
  1. IgG immunoglobin G, CH50 median hemolytic complement, IgA immunoglobin A, PLT platelet, PLR positive likelihood ratio, NLR negative likelihood ratio, PPV positive predication value, NPV negative prediction value, Sen sensitivity, Spe specificity
  2. *ESR belongs to the Kerr criteria and is used as the control here
  3. #In the ROC curves, the disease activity status discrimination for albumin and haemoglobin is “0” (i.e. Inactive disease)