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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?

Fig. 6

Targeting JAKs or glycolytic enzymes inhibits the development of a glycolytic and pro-inflammatory SF phenotype. OASF were cultured with or without stimulation by ThCM in the presence or absence of different concentrations of baricitinib, tofacitinib or the glycolytic inhibitors 3-BrPa and FX11. After 4 days of culture, supernatants were harvested, and the lactate concentrations and the ratio of glycolytic to oxidative glucose metabolism (a, c) as well as the secretion of IL-6 and MMP3 (b and d) were determined (n = 7). Results are presented as the mean ± SEM. *p < 0.05, Wilcoxon signed-rank test. 3-BrPa, 3-bromopyruvate

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