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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Lymphatic muscle cells contribute to dysfunction of the synovial lymphatic system in inflammatory arthritis in mice

Fig. 2

Reduced lymphatic muscle cell coverage in mature lymphatic vessels that drain arthritic joints of TNF-Tg mice. Ankle tissues from Fig. 1 were subjected to whole-mount double immunofluorescence staining with CD31 (red) and α-smooth muscle actin (αSMA, green) antibodies to identify CD31 and αSMA double-positive mature LVs (indicated by white arrows). a Representative images (magnification × 10) show reduced vessels that are covered by αSMA+ LMCs in 2.5- and 5-month-old TNF-Tg mice. b Quantification of the percentage of vessels that are covered by αSMA+ LMCs. Values are mean ± SD. n = 8–9 legs from 4 to 7 mice per group. *p < 0.05 by the Student t test

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