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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Elucidating the cellular mechanism for E2-induced dermal fibrosis

Fig. 4

E2-induced transcription of ECM components and pro-fibrotic mediators ex vivo. Steady-state mRNA levels of TGFβ2 (a), Col22A1 (b), TGFβ1 (c), Col I IA2 (d), Col IIIA1 (e), and FN (f) at 24 (a), 48 (b, c), or 72 (df) h post vehicle vs. E2 stimulation of human skin ex vivo. Bars = mean ± SEM. Normalized to B2M (ae) and GAPDH (f). Data shown are from ≥ 8 independent experiments using human skin tissue from ≥ 8 different donors. Statistical test: Two-tailed, parametric, paired t test (ad, f), Wilcoxon matched-pairs signed rank test (e). *p ≤ 0.05

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