Fig. 5
From: Elucidating the cellular mechanism for E2-induced dermal fibrosis
Col22A1 transcription post E2 stimulation and TGFβ1 signaling blockade ex vivo. Steady-state transcript levels of Col22A1 during a 1 h pre-treatment with the TGFβ type I receptor inhibitor, SB-431542, 48 h post E2 stimulation, ex vivo. Ethanol, ETOH; estradiol, E2, dimethyl sulfoxide, DMSO, normalized to B2M. Bars = mean ± SEM. Data shown are from ≥ 6 independent experiments using human skin from ≥ 6 different donors. Statistical test: Parametric one-way ANOVA with Sidak’s multiple comparisons post hoc test. **p ≤ 0.01, ***p ≤ 0.005