Fig. 6
From: Elucidating the cellular mechanism for E2-induced dermal fibrosis
Col22A1 transcription post E2 signaling blockade ex vivo. Steady-state transcript levels of Col22A1 following a 1 h pre-treatment with the ERα inhibitor, fulvestrant, 24 h post E2 stimulation of human skin ex vivo. Dotted line indicates normalization to baseline treatment with ETOH alone. Ethanol, ETOH; estradiol, E2. Normalized to B2M. Bars = mean ± SEM. Data shown are from human skin tissue of one donor performed in 3 independent experiments. Statistical test: Two-tailed, parametric, paired t test. ****p ≤ 0.001