Table 2 Multivariable analysis of the differences in lipid profiles between SSc patients and controls
From: HDL cholesterol efflux capacity and lipid profile in patients with systemic sclerosis
Controls (n = 115) | SSc patients (n = 73) | Univariable model | Model 1 | Model 2 beta coef. (95% CI), p | ||
|---|---|---|---|---|---|---|
Lipid profile | ||||||
Cholesterol, mg/dl | 223 ± 38 | 198 ± 39 | 0.000 | 0.001 | − 22 (−37 to − 7) | 0.004 |
Triglycerides, mg/dl | 104 ± 52 | 153 ± 83 | 0.000 | 0.001 | 24 (2–47) | 0.033 |
HDL cholesterol, mg/dl | 66 ± 18 | 49 ± 13 | 0.000 | 0.000 | − 1 (− 5 to 3) | 0.75 |
LDL cholesterol, mg/dl | 136 ± 35 | 111 ± 45 | 0.000 | 0.001 | ||
LDL:HDL cholesterol ratio | 2.23 ± 0.84 | 2.50 ± 1.62 | 0.23 | 0.098 | ||
Non-HDL cholesterol, mg/dl | 157 ± 37 | 149 ± 41 | 0.24 | 0.24 | ||
Lipoprotein A, mg/dl | 16 (9–32) | 23 (12–65) | 0.020 | 0.055 | 22 (2–43) | 0.033 |
Apolipoprotein A1, mg/dl | 197 ± 34 | 168 ± 32 | 0.000 | 0.000 | − 9 (− 19 to 0) | 0.062 |
Apolipoprotein B, mg/dl | 102 ± 22 | 100 ± 26 | 0.67 | 0.52 | ||
Apo B:Apo A ratio | 0.54 ± 0.16 | 0.63 ± 0.30 | 0.024 | 0.010 | ||
Atherogenic index | 3.58 ± 0.98 | 4.37 ± 1.74 | 0.003 | 0.001 | ||
Cholesterol efflux capacity, % | 17 ± 11 | 8 ± 3 | 0.000 | 0.000 | − 6 (−10 to − 2) | 0.002 |