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Table 2 Multivariable analysis of the differences in lipid profiles between SSc patients and controls

From: HDL cholesterol efflux capacity and lipid profile in patients with systemic sclerosis

  Controls (n = 115) SSc patients (n = 73) Univariable model Model 1 Model 2
beta coef. (95% CI), p
Lipid profile
 Cholesterol, mg/dl 223 ± 38 198 ± 39 0.000 0.001 − 22 (−37 to − 7) 0.004
 Triglycerides, mg/dl 104 ± 52 153 ± 83 0.000 0.001 24 (2–47) 0.033
 HDL cholesterol, mg/dl 66 ± 18 49 ± 13 0.000 0.000 − 1 (− 5 to 3) 0.75
 LDL cholesterol, mg/dl 136 ± 35 111 ± 45 0.000 0.001   
 LDL:HDL cholesterol ratio 2.23 ± 0.84 2.50 ± 1.62 0.23 0.098   
 Non-HDL cholesterol, mg/dl 157 ± 37 149 ± 41 0.24 0.24   
 Lipoprotein A, mg/dl 16 (9–32) 23 (12–65) 0.020 0.055 22 (2–43) 0.033
 Apolipoprotein A1, mg/dl 197 ± 34 168 ± 32 0.000 0.000 − 9 (− 19 to 0) 0.062
 Apolipoprotein B, mg/dl 102 ± 22 100 ± 26 0.67 0.52   
 Apo B:Apo A ratio 0.54 ± 0.16 0.63 ± 0.30 0.024 0.010   
 Atherogenic index 3.58 ± 0.98 4.37 ± 1.74 0.003 0.001   
 Cholesterol efflux capacity, % 17 ± 11 8 ± 3 0.000 0.000 − 6 (−10 to − 2) 0.002
  1. Data represent means ± standard deviation; Model 1: Adjusted for waist circumference and statins; Model 2: Adjusted for Model 1 + rest of lipid molecules (with a p value < 0.20 in the univariable analysis) other than the one that is compared. Because collinearity LDL cholesterol, LDL:HDL ratio, non-HDL cholesterol, apoB:apoA, and atherogenic index were excluded from the multivariable analyses in Model 2, HDL high-density lipoprotein; LDL low-density lipoprotein