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Table 4 Modified Rodnan skin score association with lipid profile molecules and CV risk factors in SSc patients

From: HDL cholesterol efflux capacity and lipid profile in patients with systemic sclerosis

  Modified Rodnan skin score
  Pearson’s r p Model 1
Beta coef. (95% CI), p
Model 2
Beta coef. (95% CI), p
Age, years 0.202 0.13   
Male − 0.142 0.29   
Body mass index, kg/m2 − 0.028 0.84   
Abdominal circumference, cm −0.018 0.90   
Systolic blood pressure, mmHg 0.016 0.91   
Diastolic blood pressure, mmHg − 0.174 0.20   
Cardiovascular comorbidities     
 Smoking 0.009 0.94   
 Diabetes 0.182 0.17   
 Hypertension 0.294 0.025   
 Statins 0.109 0.41   
Analytical and lipid profiles     
 Cholesterol, mg/dl − 0.176 0.25 − 1 (−3 to 1), 0.25 −0.29 (−1.36 to 0.78), 0.59
 Triglycerides, mg/dl 0.150 0.33   
 HDL cholesterol, mg/dl 0.031 0.84   
 LDL cholesterol, mg/dl − 0.237 0.10 − 2 (− 4 to 0), 0.10  
 LDL:HDL cholesterol ratio − 0.191 0.19 − 0.03 (− 0.08 to 0.02), 0.19  
 Non-HDL cholesterol, mg/dl − 0.182 0.23 − 1 (− 3 to 1), 0.23  
 Lipoprotein A, mg/dl 0.072 0.64   
 Apolipoprotein A1, mg/dl 0.168 0.27 0.61 (− 0.80 to 2.03), 0.39  
 Apolipoprotein B, mg/dl − 0.220 0.15 − 0.91 (− 2.14 to 0.33), 0.15 − 0.04 (− 0.85 to 0.78), 0.93
 Apo B:Apo A ratio − 0.280 0.062 − 0.00 (− 0.02 to 0.00), 0.062  
 Atherogenic index − 0.100 0.51   
 Cholesterol efflux capacity, % − 0.323 0.014 − 0.19 (−  0.34 to − 0.04), 0.014 − 0.21 (− 0.37 to − 0.05), 0.011
  1. mRSS is considered the independent variable in the multivariable analyses. Model 1: adjusted for gender, age, and hypertension; Model 2: adjusted for Model 1 + rest of lipid molecules (with a p value < 0.20 in the univariable analysis) other than the one that is compared. Because collinearity parameters derived from a formula (LDL cholesterol, LDL:HDL ratio, non-HDL cholesterol, apoB:apoA, and atherogenic index) were excluded from the multivariable analyses in Model 2
  2. HDL high-density lipoprotein; LDL low-density lipoprotein